Multiple genotypes of chlamydia pneumoniae identified in human carotid plaque

M Cochrane; P Walker; H Gibbs; Peter Timms

doi:10.1099/mic.0.27781-0

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Multiple genotypes of chlamydia pneumoniae identified in human carotid plaque

Journal article

Peer reviewed

Multiple genotypes of chlamydia pneumoniae identified in human carotid plaque

M Cochrane, P Walker, H Gibbs and Peter Timms

Microbiology, Vol.151(7), pp.2285-2290

2005

DOI: https://doi.org/10.1099/mic.0.27781-0

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Abstract

PBMCs

peripheral blood mononuclear cells

VD4

variable domain 4

CAD

carotid artery disease

Chlamydia pneumoniae is an obligate intracellular respiratory pathogen that causes 10% of community-acquired pneumonia and has been associated with cardiovascular disease. Both whole-genome sequencing and specific gene typing suggest that there is relatively little genetic variation in human isolates of C. pneumoniae. To date, there has been little genomic analysis of strains from human cardiovascular sites. The genotypes of C. pneumoniae present in human atherosclerotic carotid plaque were analysed and several polymorphisms in the variable domain 4 (VD4) region of the outer-membrane protein-A (ompA) gene and the intergenic region between the ygeD and uridine kinase (ygeD-urk) genes were found. While one genotype was identified that was the same as one reported previously in humans (respiratory and cardiovascular), another genotype was found that was identical to a genotype from non-human sources (frog/koala). © 2005 SGM.

Details

Title: Multiple genotypes of chlamydia pneumoniae identified in human carotid plaque
Authors: M Cochrane (Author) - Queensland University of Technology
P Walker (Author) - Royal Brisbane Hospital
H Gibbs (Author) - Princess Alexandra Hospital
Peter Timms (Author) - Queensland University of Technology
Publication details: Microbiology, Vol.151(7), pp.2285-2290
Publisher: Microbiology Society
Date published: 2005
DOI: 10.1099/mic.0.27781-0
ISSN: 1350-0872
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99450301502621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Microbiology

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