Moving forward: a mucosal vaccine against group A streptococcus

M M Georgousakis; David J McMillan; M R Batzloff; K S Sriprakash

doi:10.1586/erv.09.33

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Moving forward: a mucosal vaccine against group A streptococcus

Journal article

Peer reviewed

Moving forward: a mucosal vaccine against group A streptococcus

M M Georgousakis, David J McMillan, M R Batzloff and K S Sriprakash

Expert Review of Vaccines, Vol.8(6), pp.747-760

2009

DOI: https://doi.org/10.1586/erv.09.33

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Abstract

mucosal adjuvant

mucosal delivery

mucosal immunity

Streptococcus pyogenes

vaccine

Streptococcus pyogenes, commonly referred to as group A streptococcus (GAS), colonizes the epithelial surfaces of the upper respiratory tract and the skin, where it causes a myriad of diseases that vary in clinical presentation and severity. Several candidate GAS vaccines are now approaching or have entered human clinical trials. However, the preclinical evaluation for the leading vaccine candidates has been premised on their ability to induce systemic protection through parenteral immunization. While systemic immunity has proven effective in preventing GAS dissemination and associated disease, it may not prove to be the optimal approach for inducing mucosal immunity against GAS. With this in mind, many researchers are moving toward testing the efficacy of their GAS vaccine candidate when delivered to the mucosal surface. This review discusses the interaction of GAS with the mucosal immune system and the approaches taken thus far in developing a mucosal GAS vaccine.

Details

Title: Moving forward: a mucosal vaccine against group A streptococcus
Authors: M M Georgousakis (Author) - Queensland Institute of Medical Research
David J McMillan (Author) - Queensland Institute of Medical Research
M R Batzloff (Author) - Queensland Institute of Medical Research
K S Sriprakash (Author) - Queensland Institute of Medical Research
Publication details: Expert Review of Vaccines, Vol.8(6), pp.747-760
Publisher: Expert Reviews Ltd.
Date published: 2009
DOI: 10.1586/erv.09.33
ISSN: 1476-0584
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450494302621
Output Type: Journal article

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Web Of Science research areas: Immunology

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