Motility changes induced by intraluminal FeSO4 in guinea pig jejunum

K Wang; R L Bertrand; S Senadheera; K E Polglaze; T V Murphy; Shaun L Sandow; Lu Liu; J C Bornstein; P P Bertrand

doi:10.1111/nmo.12276

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Motility changes induced by intraluminal FeSO4 in guinea pig jejunum

Journal article

Peer reviewed

Motility changes induced by intraluminal FeSO4 in guinea pig jejunum

K Wang, R L Bertrand, S Senadheera, K E Polglaze, T V Murphy, Shaun L Sandow, Lu Liu, J C Bornstein and P P Bertrand

Neurogastroenterology and Motility, Vol.26(3), pp.385-396

2014

DOI: https://doi.org/10.1111/nmo.12276

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Abstract

intestinal reflexes

iron supplementation

serotonin

Background: Dietary iron supplementation is associated with gastrointestinal (GI) side effects including vomiting, nausea, and diarrhea. Although inorganic iron in high concentrations may be damaging to the intestinal mucosa, we hypothesize that there are physiological effects on the GI tract that occur at concentrations achieved by supplementation. Thus, our aim was to investigate the effect of intraluminal ferrous sulfate (FeSO4) on jejunal motility. Methods: Segments of guinea pig jejunum were cannulated and the intraluminal pressure recorded with a transducer, while movements were recorded with a video camera. Peristaltic threshold was the oral pressure that evoked four consecutive propulsive contractions. The nutrients decanoic acid (1 mM), l-phenylalanine (50 mM), or the micronutrient FeSO4 (1 mM) were infused intraluminally. We also tested the effect of FeSO4 on electrochemically detected serotonin (5-HT, 5-hydroxytryptamine) released from in vitro tissues, both at rest and following mechanical stimulation. Key Results: The jejuna peristaltic threshold was significantly decreased by all three nutrients: FeSO4: 31±2-23±3 mmH2O; decanoic acid: 27±2-14±2 mmH2O; and l-phenylalanine: 30±3-14±3mmH2O. Of the three, only decanoic acid induced segmentation, while FeSO4 inhibited decanoic acid-induced segmentation. Resting 5-HT release was increased by FeSO4 (128% of control), but mechanically evoked 5-HT release was reduced (70% of control). Conclusions & Inferences: These data suggest that some luminal effects of inorganic iron on jejunal motility could be mediated through a pathway involving altered release of 5-HT. A better understanding of the interaction between luminal iron and 5-HT containing enterochromaffin cells could improve iron supplementation strategies, thus reducing side effects. © 2013 John Wiley & Sons Ltd.

Details

Title: Motility changes induced by intraluminal FeSO4 in guinea pig jejunum
Authors: K Wang (Author) - University of New South Wales
R L Bertrand (Author) - University of New South Wales
S Senadheera (Author) - University of New South Wales
K E Polglaze (Author) - University of New South Wales
T V Murphy (Author) - University of New South Wales
Shaun L Sandow (Author) - University of New South Wales
Lu Liu (Author) - University of New South Wales
J C Bornstein (Author) - University of Melbourne
P P Bertrand (Author) - University of New South Wales
Publication details: Neurogastroenterology and Motility, Vol.26(3), pp.385-396
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2014
DOI: 10.1111/nmo.12276
ISSN: 1350-1925
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99448834702621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Gastroenterology & Hepatology; Neurosciences

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