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Published VersionCC BY V4.0, Open Access
Journal article
Monitoring viral genomic sequences in transfusion-transmitted viruses
Vox Sanguinis, Vol.118(7), pp.551-558
2023
PMID: 37259832
Appears in UniSC Supported Open Access Outputs
Abstract
Background and objectives: Monitoring genomic sequences of blood-borne viruses infecting blood donors enables blood operators to undertake molecular epidemiology, confirm transfusion transmission and assess and characterize molecular and serological screening assays. The purpose of the study was to determine how blood operators globally value viral diversity surveillance and to assess its impact.
Materials and methods: An electronic questionnaire was developed and circulated to members of the International Society of Blood Transfusion-transmitted infectious diseases working party. Responses were compiled and complete data sets were analysed.
Results: Ninety-seven percent of respondents agreed that monitoring viral genomic sequences was important to blood operators and the transfusion community. However, only 47% of respondents are currently doing this monitoring. The main limitations reported were a lack of financial resources and expertise. Sequencing techniques, primarily next-generation sequencing and also Sanger sequencing, were considered most appropriate, with the preferred option for testing being regional or national reference centres. Respondents agreed that engagement with public health authorities needs to be enhanced.
Conclusion: Monitoring genomic sequences of blood-borne viruses is widely considered important by the transfusion community because of its direct applications for transfusion safety, and beyond for public health in general. Therefore, there is a need to strengthen collaboration between blood operators and public health authorities. While national and regional reference centres may be the most appropriate structure for such testing, international collaborations should not be overlooked. Overcoming financial barriers will be an important hurdle for many.
Details
- Title
- Monitoring viral genomic sequences in transfusion-transmitted viruses
- Authors
- Daniel Candotti (Corresponding Author) - Institut National de la Transfusion SanguineSteven J Drews (Author) - University of AlbertaHelen M Faddy (Author) - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
- Publication details
- Vox Sanguinis, Vol.118(7), pp.551-558
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2023
- DOI
- 10.1111/vox.13444
- ISSN
- 1423-0410; 0042-9007
- PMID
- 37259832
- Copyright note
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2023 The Authors. Vox Sanguinis published by John Wiley & Sons Ltd on behalf of International Society of Blood Transfusion.
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99734298802621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Hematology
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Source: InCites