Journal article
Molecular epidemiology of anthrax cases associated with recreational use of animal hides and yarn in the United States
PLoS One, Vol.6(12), e28274
2011
Abstract
To determine potential links between the clinical isolate to animal products and their geographic origin, we genotyped (MLVA-8, MVLA-15, and canSNP analysis) 80 environmental and 12 clinical isolates and 2 clinical specimens from five cases of anthrax (California in 1976 [n = 1], New York in 2006 [n = 1], Connecticut in 2007 [n = 2], and New Hampshire in 2009[n = 1]) resulting from recreational handling of animal products. For the California case, four clinical isolates were identified as MLVA-8 genotype (GT) 76 and in the canSNP A.Br.Vollum lineage, which is consistent with the Pakistani origin of the yarn. Twenty eight of the California isolates were in the A.Br.Vollum canSNP lineage and one isolate was in the A.Br. 003/004 canSNP sub-group. All 52 isolates and both clinical specimens related to the New York and Connecticut cases were MLVA-8 GT 1. The animal products associated with the NY and CT cases were believed to originate from West Africa, but no isolates from this region are available to be genotyped for comparison. All isolates associated with the New Hampshire case were identical and had a new genotype (GT 149). Isolates from the NY, CT and NH cases diverge from the established canSNP phylogeny near the base of the A.Br.011/009. This report illustrates the power of the current genotyping methods and the dramatically different epidemiological conditions that can lead to infections (i.e., contamination by a single genotype versus widespread contamination of numerous genotypes). These cases illustrate the need to acquire and genotype global isolates so that accurate assignments can be made about isolate origins.
Details
- Title
- Molecular epidemiology of anthrax cases associated with recreational use of animal hides and yarn in the United States
- Authors
- C K Marston (Author) - National Center for Emerging and Zoonotic Infectious Diseases, United StatesC A Allen (Author) - Northern Arizona University, United StatesJ Beaudry (Author) - Northern Arizona University, United StatesErin P Price (Author) - Northern Arizona University, United StatesS R Wolken (Author) - Northern Arizona University, United StatesT Pearson (Author) - Northern Arizona University, United StatesP Keim (Author) - Northern Arizona University, United StatesA R Hoffmaster (Author) - National Center for Emerging and Zoonotic Infectious Diseases, United States
- Publication details
- PLoS One, Vol.6(12), e28274
- Publisher
- Public Library of Science
- Date published
- 2011
- DOI
- 10.1371/journal.pone.0028274
- ISSN
- 1932-6203
- Copyright note
- This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication
- Organisation Unit
- University of the Sunshine Coast, Queensland; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450593302621
- Output Type
- Journal article
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