Journal article
Molecular drug targets for scabies: a medicinal chemistry perspective
Future Medicinal Chemistry, Vol.12(24)
2020
Abstract
Sarcoptes scabiei is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitors of host proteolytic enzymes and other proteins of interest. These discoveries remain confined to academic laboratories and institutions, failing to attract interest from researchers in commercial drug development. Here, we summarize the latest developments in the scabies mite biology and the drug targets that were subsequently identified, and we propose several peptide and nonpeptide ligands targeting the hot spots for protein–protein interactions. We also identify gaps in the development of ligands as inhibitors or modulators of these macromolecules.
Details
- Title
- Molecular drug targets for scabies: a medicinal chemistry perspective
- Authors
- Wali Inam (Author) - COMSATS Institute of Information TechnologyShelley Cavezza (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacySheraz Khan (Author) - COMSATS Institute of Information TechnologyWajahat Mahmood (Author) - COMSATS Institute of Information Technology
- Publication details
- Future Medicinal Chemistry, Vol.12(24)
- Publisher
- Future Science Ltd.
- DOI
- 10.4155/fmc-2020-0182
- ISSN
- 1756-8927
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99489706002621
- Output Type
- Journal article
Metrics
12 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Chemistry, Medicinal
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites