Logo image
Back
Molecular drug targets for scabies: a medicinal chemistry perspective
Journal article   Peer reviewed

Molecular drug targets for scabies: a medicinal chemistry perspective

Wali Inam, Shelley Cavezza, Sheraz Khan and Wajahat Mahmood
Future Medicinal Chemistry, Vol.12(24)
2020
DOI: https://doi.org/10.4155/fmc-2020-0182
PMID: 33243012
url
https://doi.org/10.4155/fmc-2020-0182View
Published Version

Abstract

protein–protein interactions drug design scabies parasitism
Sarcoptes scabiei is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitors of host proteolytic enzymes and other proteins of interest. These discoveries remain confined to academic laboratories and institutions, failing to attract interest from researchers in commercial drug development. Here, we summarize the latest developments in the scabies mite biology and the drug targets that were subsequently identified, and we propose several peptide and nonpeptide ligands targeting the hot spots for protein–protein interactions. We also identify gaps in the development of ligands as inhibitors or modulators of these macromolecules.

Details

Metrics

29 Record Views
3 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
International collaboration
Web Of Science research areas
Chemistry, Medicinal

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: SDGs from InCites

Logo image