Journal article
Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAA receptor
FEBS Letters, Vol.331(3), pp.211-216
1993
Abstract
We have isolated a cDNA, from the chicken, that encodes a fourth type of γ subunit of the vertebrate brain GABAA receptor. The mature polypeptide (which we name γ4) displays 67%, 69% and 70% identity, respectively, to the rat γ1, γ2 and γ3 subunits. In the developing chicken brain, the γ4-subunit mRNA is first detected at embryonic day 13; the transcript level then increases progressively during embryogenesis. In situ hybridization reveals that the γ4-subunit mRNA is abundant in several brain regions, including the ectostriatum, nucleus rotundus and hyperstriatum ventrale, which are involved in visual processing and learning. © 1993.
Details
- Title
- Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAA receptor
- Authors
- Robert J Harvey (Author) - Universitiit Hamburg, GermanyH C Kim (Author) - Universitiit Hamburg, GermanyM G Darlison (Author) - Universitiit Hamburg, Germany
- Publication details
- FEBS Letters, Vol.331(3), pp.211-216
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 1993
- DOI
- 10.1016/0014-5793(93)80339-V
- ISSN
- 0014-5793
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450454702621
- Output Type
- Journal article
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