Journal article
Molecular Structural Differences between Type-2-Diabetic and Healthy Glycogen
Biomacromolecules, Vol.12(6), pp.1983-1986
2011
PMID: 21591708
Abstract
Glycogen is a highly branched glucose polymer functioning as a glucose buffer in animals. Multiple-detector size exclusion chromatography and fluorophore-assisted carbohydrate electrophoresis were used to examine the structure of undegraded native liver glycogen (both whole and enzymatically del;ranched) as a function of molecular size, isolated from the liver; of healthy and db/db mice (the latter a type 2 diabetic model). Both the fully branched and debranched levels of glycogen structure showed fundamental differences between glycogen from healthy and db/db mice. Healthy glycogen had a greater population of large particles, with more a particles (tightly linked assemblages of smaller,8 particles) than glycogen from db/db mice. These structural differences suggest a new understanding of type 2 diabetes.
Details
- Title
- Molecular Structural Differences between Type-2-Diabetic and Healthy Glycogen
- Authors
- Mitchell Sullivan - University of QueenslandJiong Li - Wuhan UniversityChuanzhou Li - Wuhan UniversityFrancisco Vilaplana - University of QueenslandDavid Stapleton - University of MelbourneAngus A. Gray-Weale - Monash UniversityStirling Bowen - Southern Cross UniversityLing Zheng - Wuhan UniversityRobert G. Gilbert (Corresponding Author) - University of Queensland
- Publication details
- Biomacromolecules, Vol.12(6), pp.1983-1986
- Publisher
- American Chemical Society
- Date published
- 2011
- DOI
- 10.1021/bm2006054
- ISSN
- 1526-4602
- PMID
- 21591708
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035098802621
- Output Type
- Journal article
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- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Organic
- Polymer Science
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