Molecular Phylogeny of Edge Hill Virus Supports its Position in the Yellow Fever Virus Group and Identifies a New Genetic Variant

Joanne Macdonald; M Poidinger; J S Mackenzie; R C Russell; S L Doggett; A K Broom; D Phillips; J Potamski; G Gard; P Whelan; R Weir; Paul R Young; D Gendle; S Maher; R T Barnard; R A Hall

doi:10.4137/EBO.S4966

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Molecular Phylogeny of Edge Hill Virus Supports its Position in the Yellow Fever Virus Group and Identifies a New Genetic Variant

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Molecular Phylogeny of Edge Hill Virus Supports its Position in the Yellow Fever Virus Group and Identifies a New Genetic Variant

Joanne Macdonald, M Poidinger, J S Mackenzie, R C Russell, S L Doggett, A K Broom, D Phillips, J Potamski, G Gard, P Whelan, …

Evolutionary Bioinformatics, Vol.6, pp.91-96

2010

DOI: https://doi.org/10.4137/EBO.S4966

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Abstract

Edge Hill virus

EHV

yellow fever virus

flavivirus

Edge Hill virus (EHV) is a mosquito-borne flavivirus isolated throughout Australia during mosquito surveillance programs. While not posing an immediate threat to the human population, EHV is a taxonomically interesting flavivirus since it remains the only member of the yellow fever virus (YFV) sub-group to be detected within Australia. Here we present both an antigenic and genetic investigation of collected isolates, and confirm taxonomic classification of the virus within the YFV-group. Isolates were not clustered based on geographical origin or time of isolation, suggesting that minimal genetic evolution of EHV has occurred over geographic distance or time within the EHV cluster. However, two isolates showed significant differences in antigenic reactivity patterns, and had a much larger divergence from the EHV prototype (19% nucleotide and 6% amino acid divergence), indicating a distinct subtype or variant within the EHV subgroup.

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Title: Molecular Phylogeny of Edge Hill Virus Supports its Position in the Yellow Fever Virus Group and Identifies a New Genetic Variant
Authors: Joanne Macdonald (Author) - University of Queensland
M Poidinger (Author) - University of Queensland
J S Mackenzie (Author) - University of Queensland
R C Russell (Author) - University of Sydney
S L Doggett (Author) - University of Sydney
A K Broom (Author) - University of Western Australia
D Phillips (Author) - Queensland Health Forensic and Scientific Services
J Potamski (Author) - Queensland Health Forensic and Scientific Services
G Gard (Author) - Berrimah Veterinary Laboratories
P Whelan (Author) - Queensland Health Forensic and Scientific Services
R Weir (Author) - NT Department of Health and Families
Paul R Young (Author) - University of Queensland
D Gendle (Author) - University of Queensland
S Maher (Author) - University of Queensland
R T Barnard (Author) - University of Queensland
R A Hall (Author) - University of Queensland
Publication details: Evolutionary Bioinformatics, Vol.6, pp.91-96
Publisher: Libertas Academica Ltd.
Date published: 2010
DOI: 10.4137/EBO.S4966
ISSN: 1176-9343
Copyright note: Copyright © 2010 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450380902621
Output Type: Journal article

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