Journal article
Molecular Mechanisms of Antipsychotic Drug-Induced Diabetes
Frontiers in Neuroscience, Vol.11, 643
2017
Abstract
Antipsychotic drugs (APDs) are widely prescribed to control various mental disorders. As mental disorders are chronic diseases, these drugs are often used over a life-time. However, APDs can cause serious glucometabolic side-effects including type 2 diabetes and hyperglycaemic emergency, leading to medication non-compliance. At present, there is no effective approach to overcome these side-effects. Understanding the mechanisms for APD-induced diabetes should be helpful in prevention and treatment of these side-effects of APDs and thus improve the clinical outcomes of APDs. In this review, the potential mechanisms for APD-induced diabetes are summarized so that novel approaches can be considered to relieve APD-induced diabetes. APD-induced diabetes could be mediated by multiple mechanisms: (1) APDs can inhibit the insulin signaling pathway in the target cells such as muscle cells, hepatocytes and adipocytes to cause insulin resistance; (2) APD-induced obesity can result in high levels of free fatty acids (FFA) and inflammation, which can also cause insulin resistance. (3) APDs can cause direct damage to β-cells, leading to dysfunction and apoptosis of β-cells. A recent theory considers that both β-cell damage and insulin resistance are necessary factors for the development of diabetes. In high-fat diet-induced diabetes, the compensatory ability of β-cells is gradually damaged, while APDs cause direct β-cell damage, accounting for the severe form of APD-induced diabetes. Based on these mechanisms, effective prevention of APD-induced diabetes may need an integrated approach to combat various effects of APDs on multiple pathways.
Details
- Title
- Molecular Mechanisms of Antipsychotic Drug-Induced Diabetes
- Authors
- Jiezhong Chen (Author) - University of QueenslandXu-Feng Huang (Author) - University of WollongongRenfu Shao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringChen Chen (Author) - University of QueenslandChao Deng (Author) - University of Wollongong
- Publication details
- Frontiers in Neuroscience, Vol.11, 643; 12
- Publisher
- Frontiers Research Foundation
- Date published
- 2017
- DOI
- 10.3389/fnins.2017.00643
- ISSN
- 1662-4548
- Copyright note
- Copyright © 2017 Chen, Huang, Shao, Chen and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451011602621
- Output Type
- Journal article
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