Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

Amelia J McFarland; Shailendra Anoopkumar-Dukie; Devinder S Arora; Gary D Grant; Catherine M McDermott; Anthony V Perkins; Andrew K Davey

doi:10.3390/ijms151120607

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Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

Journal article

Open access

Peer reviewed

Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

Amelia J McFarland, Shailendra Anoopkumar-Dukie, Devinder S Arora, Gary D Grant, Catherine M McDermott, Anthony V Perkins and Andrew K Davey

International Journal of Molecular Sciences, Vol.15(11), pp.20607-20637

2014

DOI: https://doi.org/10.3390/ijms151120607

PMCID: PMC4264186

PMID: 25391045

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Abstract

statin

cognition

central nervous system (CNS)

neurotoxicity

neuroprotection

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary and secondary prevention against cardiovascular disease and stroke. Statins' effects on the central nervous system (CNS), particularly on cognition and neurological disorders such as stroke and multiple sclerosis, have received increasing attention in recent years, both within the scientific community and in the media. Current understanding of statins' effects is limited by a lack of mechanism-based studies, as well as the assumption that all statins have the same pharmacological effect in the central nervous system. This review aims to provide an updated discussion on the molecular mechanisms contributing to statins' possible effects on cognitive function, neurodegenerative disease, and various neurological disorders such as stroke, epilepsy, depression and CNS cancers. Additionally, the pharmacokinetic differences between statins and how these may result in statin-specific neurological effects are also discussed.

Details

Title: Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System
Authors: Amelia J McFarland (Author) - Griffith University
Shailendra Anoopkumar-Dukie (Author) - Griffith University
Devinder S Arora (Author) - Griffith University
Gary D Grant (Author) - Griffith University
Catherine M McDermott (Author) - Bond University
Anthony V Perkins (Author) - Griffith University
Andrew K Davey (Corresponding Author) - Griffith University
Publication details: International Journal of Molecular Sciences, Vol.15(11), pp.20607-20637
Publisher: MDPI AG
Date published: 2014
DOI: 10.3390/ijms151120607
ISSN: 1422-0067; 1661-6596
PMID: 25391045; PMC4264186
Copyright note: © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Health; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99685295002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary

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