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Journal article
Modifiable dementia risk associated with smaller white matter volume and altered 1/f aperiodic brain activity: cross-sectional insights from the LEISURE study
Age and Ageing, Vol.53(11), pp.1-9
2024
Appears in Thompson Institute Research Collection
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Abstract
Background
The rising prevalence of dementia necessitates identifying early neurobiological markers of dementia risk. Reduced cerebral white matter volume and flattening of the slope of the electrophysiological 1/f spectral power distribution provide neurobiological markers of brain ageing alongside cognitive decline. However, their association with modifiable dementia risk remains to be understood.
Methods
A cross-sectional sample of 98 healthy older adults (79 females, mean age = 65.44) underwent structural magnetic resonance imaging (sMRI), resting-state electroencephalography (EEG), cognitive assessments and dementia risk scoring using the CogDrisk framework. Univariate and multivariate linear regression models were conducted to investigate the relationships between modifiable dementia risk and sMRI brain volumes, the exponent of EEG 1/f spectral power, and cognition, whilst controlling for non-modifiable factors.
Results
Smaller global white matter volume (F(1,87) = 6.884, R2 = 0.073, P = .010), and not grey (F(1,87) = 0.540, R2 = 0.006, P = .468) or ventricle volume (F(1,87) = 0.087, R2 = 0.001, P = .769), was associated with higher modifiable dementia risk. A lower exponent, reflecting a flatter 1/f spectral power distribution, was associated with higher dementia risk at frontal (F(1,92) = 4.096, R2 = 0.043, P = .046) but not temporal regions. No significant associations were found between cognitive performance and dementia risk. In multivariate analyses, both white matter volume and the exponent of the 1/f spectral power distribution independently associated with dementia risk.
Conclusions
Structural and functional neurobiological markers of early brain ageing, but not cognitive function, are independently associated with modifiable dementia risk in healthy older adults.
Details
- Title
- Modifiable dementia risk associated with smaller white matter volume and altered 1/f aperiodic brain activity: cross-sectional insights from the LEISURE study
- Authors
- Thomas Pace (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJacob M Levenstein - University of the Sunshine Coast, Queensland, Thompson InstituteToomas E Anijärv - University of the Sunshine Coast, Queensland, Thompson InstituteAlicia J Campbell - University of the Sunshine Coast, Queensland, Thompson InstituteCiara Treacy - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel F Hermens - University of the Sunshine Coast, Queensland, Thompson InstituteSophie C Andrews - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Age and Ageing, Vol.53(11), pp.1-9
- Publisher
- Oxford University Press
- Date published
- 2024
- DOI
- 10.1093/ageing/afae243
- ISSN
- 1468-2834; 0002-0729
- Copyright note
- © The Author(s) 2024. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com. This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com
- Grant note
- This study presents independent research supported by the Wilson Foundation.
- Organisation Unit
- Healthy Ageing Research Cluster; Thompson Institute
- Language
- English
- Record Identifier
- 991078297402621
- Output Type
- Journal article
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