Modelling associations between neurocognition and functional course in young people with emerging mental disorders: a longitudinal cohort study

Jacob J Crouse; Kate M Chitty; Frank Iorfino; Joanne S Carpenter; Django White; Alissa Nichles; Natalia Zmicerevska; Adam J Guastella; Elizabeth M Scott; Rico S C Lee; Sharon L Naismith; Jan Scott; Daniel F Hermens; Ian B Hickie

doi:10.1038/s41398-020-0726-9

Back

Modelling associations between neurocognition and functional course in young people with emerging mental disorders: a longitudinal cohort study

Journal article

Open access

Peer reviewed

Modelling associations between neurocognition and functional course in young people with emerging mental disorders: a longitudinal cohort study

Jacob J Crouse, Kate M Chitty, Frank Iorfino, Joanne S Carpenter, Django White, Alissa Nichles, Natalia Zmicerevska, Adam J Guastella, Elizabeth M Scott, Rico S C Lee, …

Translational Psychiatry, Vol.10, 22

2020

DOI: https://doi.org/10.1038/s41398-020-0726-9

Appears in Thompson Institute Research Collection

Files and links (2)

pdf

PDF - Published Version (Open Access)403.25 kBDownload View

Published VersionPDF - Published Version (Open Access)CC BY V4.0, Open Access

url

https://doi.org/10.1038/s41398-020-0726-9View

Published Version

Abstract

Other Collaborations

Thompson Institute Special Collection

UniSC Diversity Area - Disability and Inclusion

Neurocognitive impairment is commonly associated with functional disability in established depressive, bipolar and psychotic disorders. However, little is known about the longer-term functional implications of these impairments in early phase transdiagnostic cohorts. We aimed to examine associations between neurocognition and functioning at baseline and over time. We used mixed effects models to investigate associations between neurocognitive test scores and longitudinal social and occupational functioning ("Social and Occupational Functioning Assessment Scale") at 1-7 timepoints over five-years in 767 individuals accessing youth mental health services. Analyses were adjusted for age, sex, premorbid IQ, and symptom severity. Lower baseline functioning was associated with male sex (coefficient -3.78, 95% CI -5.22 to -2.34 p < 0.001), poorer verbal memory (coefficient 0.90, 95% CI 0.42 to 1.38, p < 0.001), more severe depressive (coefficient -0.28, 95% CI -0.41 to -0.15, p < 0.001), negative (coefficient -0.49, 95% CI -0.74 to -0.25, p < 0.001), and positive symptoms (coefficient -0.25, 95% CI -0.41 to -0.09, p = 0.002) and lower premorbid IQ (coefficient 0.13, 95% CI 0.07 to 0.19, p < 0.001). The rate of change in functioning over time varied among patients depending on their sex (male; coefficient 0.73, 95% CI 0.49 to 0.98, p < 0.001) and baseline level of cognitive flexibility (coefficient 0.14, 95% CI 0.06 to 0.22, p < 0.001), such that patients with the lowest scores had the least improvement in functioning. Impaired cognitive flexibility is common and may represent a meaningful and transdiagnostic target for cognitive remediation in youth mental health settings. Future studies should pilot cognitive remediation targeting cognitive flexibility while monitoring changes in functioning.

Details

Title: Modelling associations between neurocognition and functional course in young people with emerging mental disorders: a longitudinal cohort study
Authors: Jacob J Crouse (Author) - University of Sydney
Kate M Chitty (Author) - University of Sydney
Frank Iorfino (Author) - University of Sydney
Joanne S Carpenter (Author) - University of Sydney
Django White (Author) - University of Sydney
Alissa Nichles (Author) - University of Sydney
Natalia Zmicerevska (Author) - University of Sydney
Adam J Guastella (Author) - University of Sydney
Elizabeth M Scott (Author) - University of Notre Dame
Rico S C Lee (Author) - Monash University
Sharon L Naismith (Author) - University of Sydney
Jan Scott (Author) - Newcastle University, United Kingdom
Daniel F Hermens (Author) - University of the Sunshine Coast - Thompson Institute
Ian B Hickie (Author) - University of Sydney
Publication details: Translational Psychiatry, Vol.10, 22; 9
Publisher: Nature Publishing Group
Date published: 2020
DOI: 10.1038/s41398-020-0726-9
ISSN: 2158-3188
Copyright note: Copyright © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450850802621
Output Type: Journal article

Metrics

7 File views/ downloads

49 Record Views

11 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites