Modeling of the hemodynamic responses in block design fMRI studies

Zack Y Shan; M J Wright; P M Thompson; K L McMahon; G G A M Blokland; G I De Zubicaray; N G Martin; A A E Vinkhuyzen; D C Reutens

doi:10.1038/jcbfm.2013.200

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Modeling of the hemodynamic responses in block design fMRI studies

Journal article

Peer reviewed

Modeling of the hemodynamic responses in block design fMRI studies

Zack Y Shan, M J Wright, P M Thompson, K L McMahon, G G A M Blokland, G I De Zubicaray, N G Martin, A A E Vinkhuyzen and D C Reutens

Journal of Cerebral Blood Flow and Metabolism, Vol.34(2), pp.316-324

2014

DOI: https://doi.org/10.1038/jcbfm.2013.200

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Abstract

fMRI

hemodynamic response

hemodynamic response function

test-retest reliability

The hemodynamic response function (HRF) describes the local response of brain vasculature to functional activation. Accurate HRF modeling enables the investigation of cerebral blood flow regulation and improves our ability to interpret fMRI results. Block designs have been used extensively as fMRI paradigms because detection power is maximized; however, block designs are not optimal for HRF parameter estimation. Here we assessed the utility of block design fMRI data for HRF modeling. The trueness (relative deviation), precision (relative uncertainty), and identifiability (goodness-of-fit) of different HRF models were examined and test-retest reproducibility of HRF parameter estimates was assessed using computer simulations and fMRI data from 82 healthy young adult twins acquired on two occasions 3 to 4 months apart. The effects of systematically varying attributes of the block design paradigm were also examined. In our comparison of five HRF models, the model comprising the sum of two gamma functions with six free parameters had greatest parameter accuracy and identifiability. Hemodynamic response function height and time to peak were highly reproducible between studies and width was moderately reproducible but the reproducibility of onset time was low. This study established the feasibility and test-retest reliability of estimating HRF parameters using data from block design fMRI studies.

Details

Title: Modeling of the hemodynamic responses in block design fMRI studies
Authors: Zack Y Shan (Author) - University of Queensland
M J Wright (Author) - Queensland Institute of Medical Research
P M Thompson (Author) - UCLA School of Medicine, United States
K L McMahon (Author) - University of Queensland
G G A M Blokland (Author) - Queensland Institute of Medical Research
G I De Zubicaray (Author) - University of Queensland
N G Martin (Author) - Queensland Institute of Medical Research
A A E Vinkhuyzen (Author) - University of Queensland
D C Reutens (Author) - University of Queensland
Publication details: Journal of Cerebral Blood Flow and Metabolism, Vol.34(2), pp.316-324
Publisher: Sage Publications Ltd.
DOI: 10.1038/jcbfm.2013.200
ISSN: 0271-678X
Organisation Unit: Thompson Institute; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450752402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Endocrinology & Metabolism; Hematology; Neurosciences

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