Journal article
Mitochondrial transformations in the aging human placenta
American Journal of Physiology: Endocrinology and Metabolism, Vol.319(6), pp.E981-E994
2020
PMID: 32954826
Abstract
Mitochondria play a key role in homeostasis and are central to one of the leading hypotheses of aging, the free radical theory. Mitochondria function as a reticulated network, constantly adapting to the cellular environment through fusion (joining), biogenesis (formation of new mitochondria), and fission (separation). This adaptive response is particularly important in response to oxidative stress, cellular damage, and aging, when mitochondria are selectively removed through mitophagy, a mitochondrial equivalent of autophagy. During this complex process, mitochondria influence surrounding cell biology and organelles through the release of signaling molecules. Given that the human placenta is a unique organ having a transient and somewhat defined life span of similar to 280 days, any adaption or dysfunction associated with mitochondrial physiology as a result of aging will have a dramatic impact on the health and function of both the placenta and the fetus. Additionally, a defective placenta during gestation, resulting in reduced fetal growth, has been shown to influence the development of chronic disease in later life. In this review we focus on the mitochondrial adaptions and transformations that accompany gestational length and share similarities with age-related diseases. In addition, we discuss the role of such changes in regulating placental function throughout gestation, the etiology of gestational complications, and the development of chronic diseases later in life.
Details
- Title
- Mitochondrial transformations in the aging human placenta
- Authors
- Lucy A. Bartho (Author) - Griffith UniversityJoshua J. Fisher (Author) - University of Newcastle AustraliaJames S. M. Cuffe (Author) - The University of QueenslandAnthony V Perkins (Corresponding Author) - Griffith University
- Publication details
- American Journal of Physiology: Endocrinology and Metabolism, Vol.319(6), pp.E981-E994
- Publisher
- American Physiological Society
- Date published
- 2020
- DOI
- 10.1152/ajpendo.00354.2020
- ISSN
- 1522-1555; 0193-1849
- PMID
- 32954826
- Copyright note
- © 2020 American Physiological Society . This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685298202621
- Output Type
- Journal article
Metrics
158 File views/ downloads
13 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Endocrinology & Metabolism
- Physiology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites