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Published VersionCC BY V4.0, Open Access
Journal article
Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review
Cells, Vol.11(16), pp.1-24
2022
PMCID: PMC9406893
PMID: 36010558
Abstract
Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease (DKD). Compared to the vast body of evidence from preclinical in vitro and in vivo studies, evidence from human studies is limited. In a comprehensive search of the published literature, findings from studies that reported evidence of mitochondrial dysfunction in individuals with DKD were examined. Three electronic databases (PubMed, Embase, and Scopus) were searched in March 2022. A total of 1339 articles were identified, and 22 articles met the inclusion criteria. Compared to non-diabetic controls (NDC) and/or individuals with diabetes but without kidney disease (DC), individuals with DKD (age ~55 years; diabetes duration ~15 years) had evidence of mitochondrial dysfunction. Individuals with DKD had evidence of disrupted mitochondrial dynamics (11 of 11 articles), uncoupling (2 of 2 articles), oxidative damage (8 of 8 articles), decreased mitochondrial respiratory capacity (1 of 1 article), decreased mtDNA content (5 of 6 articles), and decreased antioxidant capacity (3 of 4 articles) compared to ND and/or DC. Neither diabetes nor glycemic control explained these findings, but rather presence and severity of DKD may better reflect degree of mitochondrial dysfunction in this population. Future clinical studies should include individuals closer to diagnosis of diabetes to ascertain whether mitochondrial dysfunction is implicated in the development of, or is a consequence of, DKD.
Details
- Title
- Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review
- Authors
- Nicole Flemming (Corresponding Author) - Griffith UniversityLaura Pernoud (Author) - University of the Sunshine Coast, Queensland, School of Health - BiomedicineJosephine M Forbes (Author) - The University of QueenslandLinda Gallo (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
- Publication details
- Cells, Vol.11(16), pp.1-24
- Publisher
- MDPI AG
- Date published
- 2022
- DOI
- 10.3390/cells11162481
- ISSN
- 2073-4409
- PMID
- 36010558; PMC9406893
- Copyright note
- Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99668498702621
- Output Type
- Journal article
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