Mitigating the Risk of Transfusion-Transmitted Dengue in Australia

Kelly Rooks; Clive R Seed; Jesse J Fryk; Catherine A Hyland; Robert J Harley; Jerry A Holmberg; Denese C Marks; Robert L P Flower; Helen M Faddy

doi:10.1155/2016/3059848

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Mitigating the Risk of Transfusion-Transmitted Dengue in Australia

Journal article

Open access

Peer reviewed

Mitigating the Risk of Transfusion-Transmitted Dengue in Australia

Kelly Rooks, Clive R Seed, Jesse J Fryk, Catherine A Hyland, Robert J Harley, Jerry A Holmberg, Denese C Marks, Robert L P Flower and Helen M Faddy

Journal of Blood Transfusion, Vol.2016, 3059848

2016

DOI: https://doi.org/10.1155/2016/3059848

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Abstract

Clinical Sciences

Cardiovascular Medicine and Haematology

Immunology

Dengue viruses (DENV 1-4) are a risk to transfusion safety, with several transfusion-transmitted (TT) cases reported globally. DENV 1-4 are endemic in over 100 countries, with seasonal outbreaks occurring in northeastern Australia. To mitigate TT-DENV risk in Australia, fresh blood components are not manufactured from donors returning from any area (domestic/overseas) with known dengue transmission. Alternatively, TT-DENV risk may be mitigated using an appropriate blood donor screening assay. We aimed to determine the rate of dengue infection in donors during dengue outbreaks in Australia. Plasma samples were collected from blood donors during local dengue outbreaks. All samples were tested for the presence of DENV RNA and selected samples were tested for DENV antigen (nonstructural protein 1, NS1) with two assays. No donors residing in high risk areas had detectable levels of DENV RNA or NS1 and no cases of DENV viremia were detected in blood donors residing in areas of Australia experiencing DENV outbreaks. Definitive conclusions could not be drawn from this study; however, the lack of detection of DENV RNA or antigen in donations suggests that the current risk of TT-DENV is low and maintaining the fresh component restriction for "at-risk" donors is appropriate.

Details

Title: Mitigating the Risk of Transfusion-Transmitted Dengue in Australia
Authors: Kelly Rooks (Author) - Australian Red Cross Blood Service
Clive R Seed (Author) - Australian Red Cross Blood Service
Jesse J Fryk (Author) - Australian Red Cross Blood Service
Catherine A Hyland (Author) - Australian Red Cross Blood Service
Robert J Harley (Author) - Australian Red Cross Blood Service
Jerry A Holmberg (Author) - Grifols Diagnostic Solutions, United States
Denese C Marks (Author) - Australian Red Cross Blood Service
Robert L P Flower (Author) - Australian Red Cross Blood Service
Helen M Faddy (Author) - University of Queensland
Publication details: Journal of Blood Transfusion, Vol.2016, 3059848; 6
Publisher: Hindawi Publishing Corporation
Date published: 2016
DOI: 10.1155/2016/3059848
ISSN: 2090-9187; 2090-9187
Copyright note: Copyright © 2016 Kelly Rooks et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451412602621
Output Type: Journal article

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