Journal article
Mismatch Negativity/P3a Complex in Young People with Psychiatric Disorders: A Cluster Analysis
PLoS One, Vol.7(12), e51871
2012
Abstract
Background: We have recently shown that the event-related potential biomarkers, mismatch negativity (MMN) and P3a, are similarly impaired in young patients with schizophrenia- and affective-spectrum psychoses as well as those with bipolar disorder. A data driven approach may help to further elucidate novel patterns of MMN/P3a amplitudes that characterise distinct subgroups in patients with emerging psychiatric disorders. Methods: Eighty seven outpatients (16 to 30 years) were assessed: 19 diagnosed with a depressive disorder; 26 with a bipolar disorder; and 42 with a psychotic disorder. The MMN/P3a complex was elicited using a two-tone passive auditory oddball paradigm with duration deviant tones. Hierarchical cluster analysis utilising frontal, central and temporal neurophysiological variables was conducted. Results: Three clusters were determined: the 'globally impaired' cluster (n = 53) displayed reduced frontal and temporal MMN as well as reduced central P3a amplitudes; the 'largest frontal MMN' cluster (n = 17) were distinguished by increased frontal MMN amplitudes and the 'largest temporal MMN' cluster (n = 17) was characterised by increases in temporal MMN only. Notably, 55% of those in the globally impaired cluster were diagnosed with schizophrenia-spectrum disorder, whereas the three patient subgroups were equally represented in the remaining two clusters. The three cluster-groups did not differ in their current symptomatology; however, the globally impaired cluster was the most neuropsychologically impaired, compared with controls. Conclusions: These findings suggest that in emerging psychiatric disorders there are distinct MMN/P3a profiles of patient subgroups independent of current symptomatology. Schizophrenia-spectrum patients tended to show the most global impairments in this neurophysiological complex. Two other subgroups of patients were found to have neurophysiological profiles suggestive of quite different neurobiological (and hence, treatment) implications. © 2012 Kaur et al.
Details
- Title
- Mismatch Negativity/P3a Complex in Young People with Psychiatric Disorders: A Cluster Analysis
- Authors
- M Kaur (Author) - University of SydneyJim Lagopoulos (Author) - University of SydneyP B Ward (Author) - University of New South WalesT L Watson (Author) - University of SydneyS L Naismith (Author) - University of SydneyI B Hickie (Author) - University of SydneyDaniel F Hermens (Author) - University of Sydney
- Publication details
- PLoS One, Vol.7(12), e51871
- Publisher
- Public Library of Science
- Date published
- 2012
- DOI
- 10.1371/journal.pone.0051871
- ISSN
- 1932-6203
- Copyright note
- Copyright © 2012 Kaur et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99449918002621
- Output Type
- Journal article
Metrics
36 File views/ downloads
463 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Psychiatry
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites