Journal article
Mild Cognitive Impairment Subtypes in Older People with Depressive Symptoms: Relationship with Clinical Variables and Hippocampal Change
Journal of Geriatric Psychiatry and Neurology, Vol.28(3), pp.174-183
2015
Abstract
Aims: To examine the rates and clinical characteristics of mild cognitive impairment (MCI) in older people with depressive symptoms and to determine the relative contribution of hippocampal volume and MCI to memory change. Method: One hundred and fifty-two participants with lifetime Major Depression and remitted or mild symptoms and 28 healthy controls underwent psychiatric and neuropsychological assessments. Magnetic resonance imaging was also conducted in a subset of the patients (n = 81) and healthy controls (n = 18). Results: MCI was diagnosed in 75.7% of the patients and was associated with increasing age, medical burden, vascular risk factors, later age of depression onset and smaller hippocampi. Multiple regression showed that both hippocampal volume and MCI diagnosis mediate memory performance in depression. Conclusions: MCI occurs in older adults with a history of depression and is not simply due to symptom severity. Memory change is linked to underlying hippocampal atrophy in this patient group. © The Author(s) 2015.
Details
- Title
- Mild Cognitive Impairment Subtypes in Older People with Depressive Symptoms: Relationship with Clinical Variables and Hippocampal Change
- Authors
- H K Jayaweera (Author) - University of SydneyI B Hickie (Author) - University of SydneyS L Duffy (Author) - University of SydneyDaniel F Hermens (Author) - University of SydneyL Mowszowski (Author) - University of SydneyK Diamond (Author) - University of SydneyZ Terpening (Author) - University of SydneyM Paradise (Author) - University of SydneyS J G Lewis (Author) - University of SydneyJim Lagopoulos (Author) - University of SydneyS L Naismith (Author) - University of Sydney
- Publication details
- Journal of Geriatric Psychiatry and Neurology, Vol.28(3), pp.174-183
- Publisher
- Sage Publications Inc.
- Date published
- 2015
- DOI
- 10.1177/0891988715573535
- ISSN
- 0891-9887
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450095502621
- Output Type
- Journal article
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- Web Of Science research areas
- Clinical Neurology
- Geriatrics & Gerontology
- Psychiatry
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Source: InCites