Midkine and chronic kidney disease–associated multisystem organ dysfunctions

Victoria K Campbell; Ryan P Gately; Rathika Krishnasamy; Dominic Burg; Graham R Robertson; Nicholas A Gray

doi:10.1093/ndt/gfaa084

Back

Midkine and chronic kidney disease–associated multisystem organ dysfunctions

Journal article

Peer reviewed

Midkine and chronic kidney disease–associated multisystem organ dysfunctions

Victoria K Campbell, Ryan P Gately, Rathika Krishnasamy, Dominic Burg, Graham R Robertson and Nicholas A Gray

Nephrology, Dialysis, Transplantation, Vol.36(9), pp.1577-1584

2021

DOI: https://doi.org/10.1093/ndt/gfaa084

PMID: 32542315

Files and links (1)

url

https://doi.org/10.1093/ndt/gfaa084View

Published Version

Abstract

biomarker

chronic kidney disease

Midkine

progression

Review

Chronic kidney disease (CKD) is a progressive multisystem condition with yet undefined mechanistic drivers and multiple implicated soluble factors. If identified, these factors could be targeted for therapeutic intervention for a disease that currently lacks specific treatment. There is increasing preclinical evidence that the heparin/endothelial glycocalyx-binding molecule midkine (MK) has a pathological role in multiple CKD-related, organ-specific disease processes, including CKD progression, hypertension, vascular and cardiac disease, bone disease and CKD-related cancers. Concurrent with this are studies documenting increases in circulating and urine MK proportional to glomerular filtration rate (GFR) loss in CKD patients and evidence that administering soluble MK reverses the protective effects of MK deficiency in experimental kidney disease. This review summarizes the growing body of evidence supporting MK’s potential role in driving CKD-related multisystem disease, including MK’s relationship with the endothelial glycocalyx, the deranged MK levels and glycocalyx profile in CKD patients and a proposed model of MK organ interplay in CKD disease processes and highlights the importance of ongoing research into MK’s potential as a therapeutic target.

Details

Title: Midkine and chronic kidney disease–associated multisystem organ dysfunctions
Authors: Victoria K Campbell (Corresponding Author) - Sunshine Coast University Hospital (Australia)
Ryan P Gately (Author) - Sunshine Coast University Hospital (Australia)
Rathika Krishnasamy (Author) - Sunshine Coast University Hospital (Australia)
Dominic Burg (Author) - LYRAMID Ltd, Sydney, New South Wales, Australia
Graham R Robertson (Author) - LYRAMID Ltd, Sydney, New South Wales, Australia
Nicholas A Gray (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
Publication details: Nephrology, Dialysis, Transplantation, Vol.36(9), pp.1577-1584
Publisher: Oxford University Press
Date published: 2021
DOI: 10.1093/ndt/gfaa084
ISSN: 1460-2385
PMID: 32542315
Organisation Unit: UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99482294702621
Output Type: Journal article

Metrics

54 Record Views

9 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Transplantation; Urology & Nephrology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: SDGs from InCites