Journal article
Midkine and chronic kidney disease–associated multisystem organ dysfunctions
Nephrology, Dialysis, Transplantation, Vol.36(9), pp.1577-1584
2021
Abstract
Chronic kidney disease (CKD) is a progressive multisystem condition with yet undefined mechanistic drivers and multiple implicated soluble factors. If identified, these factors could be targeted for therapeutic intervention for a disease that currently lacks specific treatment. There is increasing preclinical evidence that the heparin/endothelial glycocalyx-binding molecule midkine (MK) has a pathological role in multiple CKD-related, organ-specific disease processes, including CKD progression, hypertension, vascular and cardiac disease, bone disease and CKD-related cancers. Concurrent with this are studies documenting increases in circulating and urine MK proportional to glomerular filtration rate (GFR) loss in CKD patients and evidence that administering soluble MK reverses the protective effects of MK deficiency in experimental kidney disease. This review summarizes the growing body of evidence supporting MK’s potential role in driving CKD-related multisystem disease, including MK’s relationship with the endothelial glycocalyx, the deranged MK levels and glycocalyx profile in CKD patients and a proposed model of MK organ interplay in CKD disease processes and highlights the importance of ongoing research into MK’s potential as a therapeutic target.
Details
- Title
- Midkine and chronic kidney disease–associated multisystem organ dysfunctions
- Authors
- Victoria K Campbell (Corresponding Author) - Sunshine Coast University HospitalRyan P Gately (Author) - Sunshine Coast University HospitalRathika Krishnasamy (Author) - Sunshine Coast University HospitalDominic Burg (Author) - LYRAMID Ltd, Sydney, New South Wales, AustraliaGraham R Robertson (Author) - LYRAMID Ltd, Sydney, New South Wales, AustraliaNicholas A Gray (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
- Publication details
- Nephrology, Dialysis, Transplantation, Vol.36(9), pp.1577-1584
- Publisher
- Oxford University Press
- DOI
- 10.1093/ndt/gfaa084
- ISSN
- 1460-2385
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99482294702621
- Output Type
- Journal article
Metrics
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Transplantation
- Urology & Nephrology
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Source: InCites