Journal article
Microstructural white matter tract alteration in Prader-Willi syndrome: A diffusion tensor imaging study
American Journal of Medical Genetics. Part C: Seminars in Medical Genetics, Vol.175(3), pp.362-367
2017
Abstract
Prader-Willi Syndrome (PWS) is a genetic disorder characterized by infantile hypotonia, hyperphagia, hypogonadism, growth hormone deficiency, intellectual disability, and severe emotional and behavioral problems. The brain mechanisms that underpin these disturbances are unknown. Diffusion tensor imaging (DTI) enables in vivo investigation of the microstructural integrity of white matter pathways. To date, only one study has used DTI to examine white matter alterations in PWS. However, that study used selected regions of interest, rather than a whole brain analysis. In the present study, we used diffusion tensor and magnetic resonance (T 1-weighted) imaging to examine microstructural white matter changes in 15 individuals with PWS (17-30 years) and 15 age-and-gender-matched controls. Whole-brain voxel-wise statistical analysis of FA was carried out using tract-based spatial statistics (TBSS). Significantly decreased fractional anisotropy was found localized to the left hemisphere in individuals with PWS within the splenium of the corpus callosum, the internal capsule including the posterior thalamic radiation and the inferior frontal occipital fasciculus (IFOF). Reduced integrity of these white matter pathways in individuals with PWS may relate to orientating attention, emotion recognition, semantic processing, and sensorimotor dysfunction.
Details
- Title
- Microstructural white matter tract alteration in Prader-Willi syndrome: A diffusion tensor imaging study
- Authors
- Lauren J Rice (Author) - University of SydneyJim Lagopoulos (Author) - University of the Sunshine Coast - Faculty of Arts, Business and LawMichael Brammer (Author) - University of SydneyStewart L Einfeld (Author) - University of Sydney
- Publication details
- American Journal of Medical Genetics. Part C: Seminars in Medical Genetics, Vol.175(3), pp.362-367
- Publisher
- John Wiley & Sons Inc.
- Date published
- 2017
- DOI
- 10.1002/ajmg.c.31572
- ISSN
- 1552-4868
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450338902621
- Output Type
- Journal article
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