Microstructural White Matter Changes in the Corpus Callosum of Young People with Bipolar Disorder: A Diffusion Tensor Imaging Study

Jim Lagopoulos; Daniel F Hermens; S N Hatton; J Tobias-Webb; K Griffiths; S L Naismith; E M Scott; I B Hickie

doi:10.1371/journal.pone.0059108

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Microstructural White Matter Changes in the Corpus Callosum of Young People with Bipolar Disorder: A Diffusion Tensor Imaging Study

Journal article

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Peer reviewed

Microstructural White Matter Changes in the Corpus Callosum of Young People with Bipolar Disorder: A Diffusion Tensor Imaging Study

Jim Lagopoulos, Daniel F Hermens, S N Hatton, J Tobias-Webb, K Griffiths, S L Naismith, E M Scott and I B Hickie

PLoS One, Vol.8(3), e59108

2013

DOI: https://doi.org/10.1371/journal.pone.0059108

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Abstract

To date, most studies of white matter changes in Bipolar Disorder (BD) have been conducted in older subjects and with well-established disorders. Studies of young people who are closer to their illness onset may help to identify core neurobiological characteristics and separate these from consequences of repeated illness episodes or prolonged treatment. Diffusion tensor imaging (DTI) was used to examine white matter microstructural changes in 58 young patients with BD (mean age 23 years; range 16-30 years) and 40 controls. Whole brain voxelwise measures of fractional anisotropy (FA), parallel diffusivity (Î»//) and radial diffusivity (Î»âŠ¥) were calculated for all subjects. White matter microstructure differences (decreased FA corrected p<.05) were found between the patients with BD and controls in the genu, body and splenium of the corpus callosum as well as the superior and anterior corona radiata. In addition, significantly increased radial diffusivity (p<.01) was found in the BD group. Neuroimaging studies of young patients with BD may help to clarify neurodevelopmental aspects of the illness and for identifying biomarkers of disease onset and progression. Our findings provide evidence of microstructural white matter changes early in the course of illness within the corpus callosum and the nature of these changes suggest they are associated with abnormalities in the myelination of axons. © 2013 Lagopoulos et al.

Details

Title: Microstructural White Matter Changes in the Corpus Callosum of Young People with Bipolar Disorder: A Diffusion Tensor Imaging Study
Authors: Jim Lagopoulos (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
S N Hatton (Author) - University of Sydney
J Tobias-Webb (Author) - University of Sydney
K Griffiths (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
E M Scott (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Publication details: PLoS One, Vol.8(3), e59108
Publisher: Public Library of Science
Date published: 2013
DOI: 10.1371/journal.pone.0059108
ISSN: 1932-6203
Copyright note: Copyright © 2013 Lagopoulos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450095702621
Output Type: Journal article

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