Methylation of the RASSF1A gene promoter in Uigur women with cervical squamous cell carcinoma in Uigur women with cervical squamous cell carcinoma

Z Pan; Jun Li; X Pan; S Chen; Z Wang; F Li; S Qu; Renfu Shao

doi:10.1700/410.4853

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Methylation of the RASSF1A gene promoter in Uigur women with cervical squamous cell carcinoma in Uigur women with cervical squamous cell carcinoma

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Methylation of the RASSF1A gene promoter in Uigur women with cervical squamous cell carcinoma in Uigur women with cervical squamous cell carcinoma

Z Pan, Jun Li, X Pan, S Chen, Z Wang, F Li, S Qu and Renfu Shao

Tumori: a journal of experimental and clinical oncology, Vol.95(1), pp.76-80

2009

DOI: https://doi.org/10.1700/410.4853

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Abstract

cervical squamous cell carcinoma

RASSF1A tumor suppressor gene

CpG island methylation

Aims and background. To explore the relationship between methylation in promoter region 2 of the Ras association domain family 1A (RASSF1A) gene and cervical squamous cell carcinoma (SCC) in Uigur women living in the Xinjiang province of China. Methods and study design. Methylation-specific polymerase chain reaction (MSP) was used to analyze 40 normal cervical epithelium samples and 65 cervical squamous cell carcinoma samples from Uigur women. Results. We found methylation in promoter region 2 of RASSF1A in 13 of the 65 cervical squamous cell carcinoma samples (20%), but not in any of the 40 normal cervical epithelium tissues. In addition, there was methylation in 7 of 46 patients with no lymph node metastases and in 6 of 19 patients with lymph node metastases. Conclusions. Our results indicate that methylation in the promoter region 2 of RASSF1A is likely associated with tumorigenesis of cervical squamous cell carcinoma in Uigur women. However, such methylation does not appear to be significantly associated with lymph node metastasis in this patient population.

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Title: Methylation of the RASSF1A gene promoter in Uigur women with cervical squamous cell carcinoma in Uigur women with cervical squamous cell carcinoma
Authors: Z Pan (Author) - Huazhong University of Science and Technology, China
Jun Li (Author) - Shihezi University, China
X Pan (Author) - Shihezi University, China
S Chen (Author) - Shihezi University, China
Z Wang (Author) - Shihezi University, China
F Li (Author) - Shihezi University, China
S Qu (Author) - Huazhong University of Science and Technology, China
Renfu Shao (Author) - University of Queensland
Publication details: Tumori: a journal of experimental and clinical oncology, Vol.95(1), pp.76-80
Publisher: Il Pensiero Scientifico Editore
Date published: 2009
DOI: 10.1700/410.4853
ISSN: 0300-8916
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449798202621
Output Type: Journal article

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