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Metformin in cardiovascular diabetology a focused review of its impact on endothelial function1.06 MB
Published VersionCC BY V4.0, Open Access
Journal article
Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function
Theranostics, Vol.11(19), pp.9376-9396
2021
Abstract
As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates glucose levels and positively affects cardiovascular function in patients with diabetes and cardiovascular complications. Endothelial dysfunction (ED) represents the primary pathological change of multiple vascular diseases, because it causes decreased arterial plasticity, increased vascular resistance, reduced tissue perfusion and atherosclerosis. Caused by "biochemical injury", ED is also an independent predictor of cardiovascular events. Accumulating evidence shows that metformin improves ED through liver kinase B1 (LKB1)/5'-adenosine monophosphat-activated protein kinase (AMPK) and AMPK-independent targets, including nuclear factor-kappa B (NF-κB), phosphatidylinositol 3 kinase-protein kinase B (PI3K-Akt), endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1), forkhead box O1 (FOXO1), krüppel-like factor 4 (KLF4) and krüppel-like factor 2 (KLF2). Evaluating the effects of metformin on endothelial cell functions would facilitate our understanding of the therapeutic potential of metformin in cardiovascular diabetology (including diabetes and its cardiovascular complications). This article reviews the physiological and pathological functions of endothelial cells and the intact endothelium, reviews the latest research of metformin in the treatment of diabetes and related cardiovascular complications, and focuses on the mechanism of action of metformin in regulating endothelial cell functions.
Details
- Title
- Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function
- Authors
- Yu Ding (Author) - University of Science and Technology of ChinaYongwen Zhou (Author) - University of Science and Technology of ChinaPing Ling (Author) - University of Science and Technology of ChinaXiaojun Feng (Author) - University of Science and Technology of ChinaSihui Luo (Author) - University of Science and Technology of ChinaXueying Zheng (Author) - University of Science and Technology of ChinaPeter J Little (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacySuowen Xu (Author) - University of Science and Technology of ChinaJianping Weng (Author) - University of Science and Technology of China
- Publication details
- Theranostics, Vol.11(19), pp.9376-9396
- Publisher
- Ivyspring International Publisher
- Date published
- 2021
- DOI
- 10.7150/thno.64706
- ISSN
- 1838-7640
- Copyright note
- © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99578408902621
- Output Type
- Journal article
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