Journal article
Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice
Carbohydrate Polymers, Vol.243, pp.1-14
2020
PMID: 32532388
Abstract
Glycogen is a branched glucose polymer involved in sustaining blood glucose homeostasis. Liver glycogen comprises α particles (up to 300 nm in diameter) made of joined β particles (∼20 nm in diameter). Glycogen α particles in a mouse model for diabetes are molecularly fragile, breaking down into smaller β particles more readily than in healthy mice. Glycogen phosphorylase (GP), a rate-limiting enzyme in glycogen degradation, is overexpressed in diabetic mice. This study shows that Metformin and Berberine, two common drugs, two common drugs used to treat diabetes, are able to revert the liver glycogen of diabetic mice to the stable structure seen in non-diabetic mice. It is also shown that these drugs reduce the GP level via the cAMP/PKA signaling pathway in diabetic livers and decrease the affinity of GP with the glycogen of db/db mice. These effects of these drugs may slow down the degradation of liver glycogen and improve glucose homeostasis.
Details
- Title
- Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice
- Authors
- Xiaocui Liu - Huazhong University of Science and TechnologyKaiping Wang - Huazhong University of Science and TechnologyJing Zhou - Union HospitalMitchell A Sullivan - Translational Research InstituteYage Liu - Huazhong University of Science and TechnologyRobert G. Gilbert - University of QueenslandBin Deng (Corresponding Author) - Huazhong University of Science and Technology
- Publication details
- Carbohydrate Polymers, Vol.243, pp.1-14
- Publisher
- Elsevier Ltd
- Date published
- 2020
- DOI
- 10.1016/j.carbpol.2020.116435
- ISSN
- 1879-1344
- PMID
- 32532388
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035095402621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Chemistry, Applied
- Chemistry, Organic
- Polymer Science
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Source: InCites