Journal article
Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer
Cancer and Metastasis Reviews, Vol.31(3), pp.469-478
2012
PMID: 22729277
Abstract
As yet, there is no cure for metastatic breast cancer. Historically, considerable research effort has been concentrated on understanding the processes of metastasis, how a primary tumour locally invades and systemically disseminates using the phenotypic switching mechanism of epithelial to mesenchymal transition (EMT); however, much less is understood about how metastases are then formed. Breast cancer metastases often look (and may even function) as ‘normal’ breast tissue, a bizarre observation against the backdrop of the organ structure of the lung, liver, bone or brain. Mesenchymal to epithelial transition (MET), the opposite of EMT, has been proposed as a mechanism for establishment of the metastatic neoplasm, leading to questions such as: Can MET be clearly demonstrated in vivo? What factors cause this phenotypic switch within the cancer cell? Are these signals/factors derived from the metastatic site (soil) or expressed by the cancer cells themselves (seed)? How do the cancer cells then grow into a detectable secondary tumour and further disseminate? And finally—Can we design and develop therapies that may combat this dissemination switch? This review aims to address these important questions by evaluating long-standing paradigms and novel emerging concepts in the field of epithelial mesencyhmal plasticity.
Details
- Title
- Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer
- Authors
- N P A Gunasinghe (Author) - University of MelbourneAlan Wells (Author) - University of PittsburghErik Thompson (Author) - University of MelbourneHonor Hugo (Author) - St Vincents Institute of Medical Research
- Publication details
- Cancer and Metastasis Reviews, Vol.31(3), pp.469-478
- Publisher
- Springer New York LLC
- DOI
- 10.1007/s10555-012-9377-5
- ISSN
- 1573-7233
- PMID
- 22729277
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99518708002621
- Output Type
- Journal article
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- Domestic collaboration
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- Web Of Science research areas
- Oncology
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Source: InCites