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Mediterranean Style Dietary Pattern with High Intensity Interval Training in Men with Prostate Cancer Treated with Androgen Deprivation Therapy - A Pilot Randomised Control Trial1.11 MB
Published VersionCC BY V4.0, Open Access
Journal article
Mediterranean Style Dietary Pattern with High Intensity Interval Training in Men with Prostate Cancer Treated with Androgen Deprivation Therapy: A Pilot Randomised Control Trial
International Journal of Environmental Research and Public Health, Vol.19(9), pp.1-17
2022
PMCID: PMC9099512
PMID: 35565100
Abstract
Background: Androgen deprivation therapy (ADT) in prostate cancer has been shown to deteriorate body composition (reduced lean mass and increased body and fat mass) and increase the risk of cardiovascular morbidity. The Mediterranean style dietary pattern (MED-diet) and high intensity interval training (HIIT) may synergistically alleviate these side effects and improve quality of life in men treated with ADT.
Methods: Twenty-three men (65.9 ± 7.8 years; body mass index: 29.6 ± 2.7 kg/m2; ADT duration: 33.8 ± 35.6 months) receiving ADT for ≥3 months were randomly assigned (1:1) to 20 weeks of usual care or the MED-diet (10 nutrition consults) with HIIT (4 × 4 min 85-95% heart rate peak, 3× week, starting at 12 weeks).
Results: The MED-diet with HIIT significantly improved cardiorespiratory fitness (+4.9 mL·kg-1·min, p < 0.001), and body mass (-3.3 kg, p < 0.001) compared to the usual care group at 20 weeks. Clinically meaningful (≥3 points) improvements were seen in quality of life and cancer-related fatigue after 20 weeks.
Conclusions: The MED-diet with HIIT increased cardiorespiratory fitness and reduced body weight in men with prostate cancer treated with ADT. Larger trials determining whether the MED-diet with HIIT translates to cardiovascular benefits are warranted.
Details
- Title
- Mediterranean Style Dietary Pattern with High Intensity Interval Training in Men with Prostate Cancer Treated with Androgen Deprivation Therapy: A Pilot Randomised Control Trial
- Authors
- Brenton J Baguley (Author) - Deakin UniversityKirsten N Adlard (Author) - The University of QueenslandDavid Jenkins (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyOlivia R L Wright (Author) - The University of QueenslandTina L Skinner (Author) - The University of Queensland
- Publication details
- International Journal of Environmental Research and Public Health, Vol.19(9), pp.1-17
- Publisher
- MDPI AG
- Date published
- 2022
- DOI
- 10.3390/ijerph19095709
- ISSN
- 1660-4601; 1661-7827
- PMID
- 35565100; PMC9099512
- Copyright note
- © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99638178502621
- Output Type
- Journal article
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