Journal article
Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome
NMR in Biomedicine, Vol.30(10), pp.1-9
2017
Abstract
Unrefreshing sleep is a hallmark of chronic fatigue syndrome/myalgic encephalomyelitis (CFS). This study examined brain structure variations associated with sleep quality in patients with CFS. 38 patients with CFS (34.8±10.1 years old) and 14 normal controls (NCs) (34.7±8.4 years old) were recruited. All subjects completed the Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index (PSQI), and Chalder Fatigue Scale (CFQ) questionnaires. Brain MRI measures included global and regional grey and white matter volumes, magnetization transfer T1 weighted (MT-T1w) intensities, and T1 weighted (T1w) and T2 weighted spin echo signal intensities. We performed voxel based group comparisons of these regional brain MRI measures and regressions of these measures with the PSQI and CFQ scales adjusted for age, anxiety and depression, and the appropriate global measure. In CFS patients, negative correlations were observed in the medial prefrontal cortex (mPFC) between PSQI and MT-T1w intensities (family-wise error corrected cluster, PFWE < 0.05) and between PSQI and T1w intensities (PFWE < 0.05). In the same mPFC location, both MT and T1w intensities were lower in CFS patients compared with NCs (uncorrected voxel P < 0.001). This study is the first to report that brain structural differences are associated with unrefreshing sleep in CFS. This result refutes the suggestion that unrefreshing sleep is a misperception in CFS patients and further investigation of this symptom is warranted.
Details
- Title
- Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome
- Authors
- Zack Y Shan (Author) - Griffith UniversityRichard Kwiatek (Author) - Lyell McEwin HospitalRichard Burnet (Author) - Royal Adelaide HospitalPeter Del Fante (Author) - Griffith UniversityDonald R Staines (Author) - Griffith UniversitySonya M Marshall-Gradisnik (Author) - Griffith UniversityLeighton R Barnden (Author) - Griffith University
- Publication details
- NMR in Biomedicine, Vol.30(10), pp.1-9
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 2017
- DOI
- 10.1002/nbm.3757
- ISSN
- 1099-1492
- Copyright note
- This is the peer reviewed version of the following article: Shan, ZY, Kwiatek, R, Burnet, R, et al. Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome. NMR in Biomedicine. 2017; 30:e3757. https://doi.org/10.1002/nbm.3757, which has been published in final form at https://doi.org/10.1002/nbm.3757. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450855802621
- Output Type
- Journal article
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