Files and links (2)
Mechanisms underlying select chemotherapeutic-agent-induced neuroinflammation and subsequent neurodegeneration917.12 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Mechanisms underlying select chemotherapeutic-agent-induced neuroinflammation and subsequent neurodegeneration
European Journal of Pharmacology, Vol.842, pp.49-56
2019
PMID: 30287154
Abstract
This review demonstrates the importance of uncovering the mechanisms that underlie chemotherapy-induced neuroinflammation. It builds upon the well-established connection between chemotherapeutic-agents and neurotoxicity along with widespread peripheral toxicities. This article summarises the major studies which have linked chemotherapy-induced neurodegeneration with direct evidence of neuroinflammation. Cancer and chemotherapy-related adverse effects impact a large proportion of the population. A better understanding of the link between chemotherapy, neurotoxicity and specifically the mechanisms of neuroinflammation, will allow the development of strategies to improve the management of side effects, and overall to reduce the burden on cancer patients receiving chemotherapy. This review has developed a summary schematic of the relationship between different chemotherapeutic agents and inflammatory markers within the central nervous system and links this correlation with some major ailments associated with chemotherapy use.
Details
- Title
- Mechanisms underlying select chemotherapeutic-agent-induced neuroinflammation and subsequent neurodegeneration
- Authors
- Fleur McLeary (Author) - Griffith UniversityArie Davis (Author) - Griffith UniversitySantosh Rudrawar (Author) - Griffith UniversityAnthony Perkins (Author) - Griffith UniversityShailendra Anoopkumar-Dukie (Corresponding Author) - Griffith University
- Publication details
- European Journal of Pharmacology, Vol.842, pp.49-56
- Publisher
- Elsevier BV
- Date published
- 2019
- DOI
- 10.1016/j.ejphar.2018.09.034
- ISSN
- 1879-0712; 0014-2999
- PMID
- 30287154
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685196602621
- Output Type
- Journal article
Metrics
176 File views/ downloads
18 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web Of Science research areas
- Pharmacology & Pharmacy
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites