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J of Applied Polymer Sci - 2024 - Babapour - Mechanics of dissolving microneedles insertion into the skin Finite element2.30 MB
Published VersionCC BY V4.0, Open Access
Journal article
Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses
Journal of Applied Polymer Science, Vol.141(38), pp.1-13
2024
Abstract
Transdermal drug delivery using dissolving microneedles (DMNs) is promising due to increased patient compliance and safety. This article presents a comprehensive simulation and experimental analysis of DMNs with varying tip and base diameters and polymers. The objective of the simulation study is to identify the optimal tip and base diameter of DMNs, as well as the most suitable polymer, for achieving maximum penetration depth. The simulation results showed that the compound consisting of polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) in a ratio of 2:1, with a tip radius of 17.5 μm and a base radius of 150 μm, achieved the deepest penetration among the different types of polymers investigated (including PVA, hyaluronic acid (HA), and PVA/PVP in ratios of 1:1 and 1:2). In addition, mechanical and skin penetration experiments were performed on PVA/PVP 2:1 DMNs with varying concentrations of 4, 7, 10, and 15% w/w to determine the optimal polymer concentration. The results of this study indicated that the optimal composition, considering the viscosity of the polymer solution and the simplicity of filling the silicone negative molds, is a PVA/PVP 2:1 with a concentration of 7% w/w.
Details
- Title
- Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses
- Authors
- Fatemeh Babapour - Tarbiat Modares UniversityZahra Faraji Rad (Corresponding Author) - University of Southern QueenslandFariba Ganji (Corresponding Author) - Tarbiat Modares University
- Publication details
- Journal of Applied Polymer Science, Vol.141(38), pp.1-13
- Publisher
- John Wiley & Sons, Inc.
- Date published
- 2024
- DOI
- 10.1002/app.55973
- ISSN
- 1097-4628; 0021-8995
- Copyright note
- © 2024 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Data Availability
- The data that support the findings of this study are available from the corresponding author upon reasonable request.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 991140405502621
- Output Type
- Journal article
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