Journal article
Mechanical Properties and Biocompatibility of Porous Titanium Scaffolds for Bone Tissue Engineering
Journal of the Mechanical Behavior of Biomedical Materials, Vol.75, pp.169-174
2017
Abstract
Synthetic scaffolds are a highly promising new approach to replace both autografts and allografts to repair and remodel damaged bone tissue. Biocompatible porous titanium scaffold was manufactured through a powder metallurgy approach. Magnesium powder was used as space holder material which was compacted with titanium powder and removed during sintering. Evaluation of the porosity and mechanical properties showed a high level of compatibility with human cortical bone. Interconnectivity between pores is higher than 95% for porosity as low as 30%. The elastic moduli are 44.2 GPa, 24.7 GPa and 15.4 GPa for 30%, 40% and 50% porosity samples which match well to that of natural bone (4-30 GPa). The yield strengths for 30% and 40% porosity samples of 221.7 MPa and 117 MPa are superior to that of human cortical bone (130-180 MPa). In-vitro cell culture tests on the scaffold samples using Human Mesenchymal Stem Cells (hMSCs) demonstrated their biocompatibility and indicated osseointegration potential. The scaffolds allowed cells to adhere and spread both on the surface and inside the pore structures. With increasing levels of porosity/interconnectivity, improved cell proliferation is obtained within the pores. It is concluded that samples with 30% porosity exhibit the best biocompatibility. The results suggest that porous titanium scaffolds generated using this manufacturing route have excellent potential for hard tissue engineering applications.
Details
- Title
- Mechanical Properties and Biocompatibility of Porous Titanium Scaffolds for Bone Tissue Engineering
- Authors
- Yunhui Chen (Author) - University of QueenslandJessica Ellen Frith (Author) - Monash UniversityAli Dehghan-Manshadi (Author) - University of QueenslandHooyar Attar (Author) - University of QueenslandDamon Kent (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringNicolas Dominique Methieu Soro (Author) - University of QueenslandMichael J Bermingham (Author) - University of QueenslandMatthew S Dargusch (Author) - University of Queensland
- Publication details
- Journal of the Mechanical Behavior of Biomedical Materials, Vol.75, pp.169-174
- Publisher
- Elsevier BV
- Date published
- 2017
- DOI
- 10.1016/j.jmbbm.2017.07.015
- ISSN
- 1751-6161; 1751-6161
- Copyright note
- Copyright © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99450518402621
- Output Type
- Journal article
- Research Statement
- false
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- Domestic collaboration
- Web Of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials
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