Journal article
Measuring mania metabolites: a longitudinal proton spectroscopy study of hypomania
Acta Psychiatrica Scandinavica. Supplementum, Vol.116(Supplement 434), pp.57-66
2007
Abstract
OBJECTIVE: Using single-voxel proton spectroscopy we aimed to investigate changes in metabolite levels in key brain regions during hypomania and euthymia in patients with bipolar disorder (BD). METHOD: Nine patients with a diagnosis of BD and nine age, sex, education, and handedness-matched comparison subjects underwent magnetic resonance proton spectroscopy (H(1)-MRS) using a 1.5 T magnet. Patients were assessed whilst hypomanic and euthymic. Metabolite (N-acetyl asparTate, NAA; myo-inositol, mI; choline, Cho) levels in the basal ganglia (BG), anterior cingulate cortex (AC), and frontal cortex (FC) were compared both between groups and within the patient group. RESULTS: Multivariate analysis revealed significant complex relationships between metabolite levels and brain regions with significant differences observed both between bipolar patients (hypomanic and euthymic) and controls, and across the two mood states. Hypomanic patients had lower mean metabolite levels when averaged across the AC and FC regions, compared with the controls. They also had a smaller difference in mean metabolite levels between the BG and FC than the control group. Euthymic patients were also found to have a smaller difference in the level of NAA between the BG and AC than the control group. CONCLUSION: This exploratory study of BD demonstrates significant differences in metabolite levels that vary both with respect to brain region and mood state. Not withstanding the confounding effects of medication and the limitation of small sample size the findings are important as they demonstrate that a longitudinal approach is a useful design especially in the context of a long-term phasic illness.
Details
- Title
- Measuring mania metabolites: a longitudinal proton spectroscopy study of hypomania
- Authors
- G S Malhi (Author) - University of SydneyB Ivanovski (Author) - Prince of Wales HospitalW Wen (Author) - University of New South WalesJim Lagopoulos (Author) - University of SydneyK Moss (Author) - University of SydneyP Sachdev (Author) - University of New South Wales
- Publication details
- Acta Psychiatrica Scandinavica. Supplementum, Vol.116(Supplement 434), pp.57-66
- Publisher
- Wiley-Blackwell Publishing Inc.
- Date published
- 2007
- DOI
- 10.1111/j.1600-0447.2007.01060.x
- ISSN
- 0065-1591; 0065-1591
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99449117902621
- Output Type
- Journal article
Metrics
379 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Psychiatry
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites