Journal article
Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth
The Journal of Physiology, Vol.597(23), pp.5597-5617
2019
PMID: 31562642
Abstract
Selenium is a trace element fundamental to diverse homeostatic processes, including anti-oxidant regulation and thyroid hormone metabolism. Selenium deficiency in pregnancy is common and increases the risk of pregnancy complications including fetal growth restriction. Although altered placental formation may contribute to these poor outcomes, the mechanism by which selenium deficiency contributes to complications in pregnancy is poorly understood. Female C57BL/6 mice were randomly allocated to control (>190 µg kg–1, n = 8) or low selenium (<50 µg kg–1, n = 8) diets 4 weeks prior to mating and throughout gestation. Pregnant mice were killed at embryonic day 18.5 followed by collection of maternal and fetal tissue. Maternal and fetal plasma thyroid hormone concentrations were analysed, as was placental expression of key selenoproteins involved in thyroid metabolism and anti-oxidant defences. Selenium deficiency increased plasma tetraiodothyronine and triiodothyronine concentrations. This was associated with a reduction in placental expression of key selenodependent deiodinases, DIO2 and DIO3. Placental expression of selenium-dependent anti-oxidants was unaffected by selenium deficiency. Selenium deficiency reduced fetal glucose concentrations, leading to reduced fetal weight. Placental glycogen content was increased within the placenta, as was Slc2a3 mRNA expression. This is the first study to demonstrate that selenium deficiency may reduce fetal weight through increased maternal thyroid hormone concentrations, impaired placental thyroid hormone metabolism and dysregulated placental nutrient transporter expression. The study suggests that the magnitude of selenium deficiency commonly reported in pregnant women may be sufficient to impair thyroid metabolism but not placental anti-oxidant concentrations.
Details
- Title
- Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth
- Authors
- Pierre Hofstee (Author) - Griffith UniversityLucy A. Bartho (Author) - Griffith UniversityDaniel R. McKeating (Author) - Griffith UniversityFilip Radenkovic (Author) - Griffith UniversityGeorgia McEnroe (Author) - Griffith UniversityJoshua J. Fisher (Author) - Griffith UniversityOlivia J. Holland (Author) - Griffith UniversityJessica J. Vanderlelie (Author) - La Trobe UniversityAnthony Perkins (Author) - Griffith UniversityJames S. M. Cuffe (Corresponding Author) - Griffith University
- Publication details
- The Journal of Physiology, Vol.597(23), pp.5597-5617
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2019
- DOI
- 10.1113/JP278473
- ISSN
- 1469-7793; 0022-3751
- PMID
- 31562642
- Copyright note
- © 2019 Physiological Society. This is the peer reviewed version of the following article: Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth, The Journal of Physiology, which has been published in final form at 10.1113/JP278473. This article may be used for noncommercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685294602621
- Output Type
- Journal article
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