Maternal gut microbiota displays minor changes in overweight and obese women with GDM

Linda Gallo; Thomas P Mullins; Kate I Tomsett; Leonie K Callaway; Harold David McIntyre; Marloes Dekker Nitert; Helen L. Barrett

doi:10.1016/j.numecd.2021.03.029

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Maternal gut microbiota displays minor changes in overweight and obese women with GDM

Journal article

Peer reviewed

Maternal gut microbiota displays minor changes in overweight and obese women with GDM

Linda Gallo, Thomas P Mullins, Kate I Tomsett, Leonie K Callaway, Harold David McIntyre, Marloes Dekker Nitert and Helen L. Barrett

Nutrition, Metabolism and Cardiovascular Diseases, Vol.31(7), pp.2131-2139

2021

DOI: https://doi.org/10.1016/j.numecd.2021.03.029

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Abstract

GDM

micorbiota

metabolism

obesity

pregnancy

gestational diabetes mellitus

Background and aims: Previous literature have shown a diversity of findings regarding the relationship between the maternal gut microbiota and gestational diabetes mellitus (GDM). We investigated the gut microbiota of overweight and obese women with gestational diabetes mellitus (GDM) against matched euglycaemic women at 16 and 28-weeks’ gestation. Methods and results: This study included women from the SPRING (Study of PRobiotics IN Gestational diabetes) cohort. Overweight and obese women with no impaired glucose tolerance or impaired fasted glucose were enrolled prior to gestational age <16 weeks. Participants with a diagnosis of GDM (n = 29) were matched with euglycaemic (n = 29) women for body mass index, probiotic or placebo intervention, maternal age, parity and ethnicity. Anthropometric, clinical and fecal microbiota (16S rRNA amplicon-based sequencing of V6–V8 region) data was assessed at 16 and 28-weeks’ gestation. The relative abundances of key bacterial genera were not significantly altered between euglycaemic women and women with GDM. Occurrence of bacterial taxa was similar between groups at both timepoints. GDM was associated with decreased Shannon diversity (p = 0.02) without differentiated clustering measured by beta diversity at 28-weeks’ gestation. Conclusions: Overweight and obese women with GDM demonstrate minor variation in the gut microbiota at 16 and 28-weeks’ gestation compared with matched euglycaemic women. This study expands on previous literature concluding the microbiota does not likely have a disease-specific characterisation in GDM.

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Title: Maternal gut microbiota displays minor changes in overweight and obese women with GDM
Authors: Linda Gallo (Author) - University of Queensland
Thomas P Mullins (Author) - University of Queensland
Kate I Tomsett (Author) - University of Queensland
Leonie K Callaway (Author) - Royal Brisbane and Women's Hospital
Harold David McIntyre (Author) - Mater Health Services
Marloes Dekker Nitert (Author) - University of Queensland
Helen L. Barrett (Author) - Mater Health Services
Publication details: Nutrition, Metabolism and Cardiovascular Diseases, Vol.31(7), pp.2131-2139
Publisher: Elsevier Ltd.
DOI: 10.1016/j.numecd.2021.03.029
ISSN: 1590-3729
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health - Biomedicine
Language: English
Record Identifier: 99620108902621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition & Dietetics

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