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Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner3.35 MB
Published VersionCC BY V4.0, Open Access
Journal article
Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner
International Journal of Molecular Sciences, Vol.22(6), pp.1-23
2021
PMID: 33799409
Abstract
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. We aimed to investigate the effect of maternal and postnatal high LA (HLA) diet on plasma FA composition, plasma and hepatic lipids and genes involved in lipid metabolism in the liver of adult offspring. Female rats were fed with low LA (LLA; 1.44% LA) or HLA (6.21% LA) diets for 10 weeks before pregnancy, and during gestation/lactation. Offspring were weaned at postnatal day 25 (PN25), fed either LLA or HLA diets and sacrificed at PN180. Postnatal HLA diet decreased circulating total n-3 PUFA and alpha-linolenic acid (ALA), while increased total n-6 PUFA, LA and arachidonic acid (AA) in both male and female offspring. Maternal HLA diet increased circulating leptin in female offspring, but not in males. Maternal HLA diet decreased circulating adiponectin in males. Postnatal HLA diet significantly decreased aspartate transaminase (AST) in females and downregulated total cholesterol, HDL-cholesterol and triglycerides in the plasma of males. Maternal HLA diet downregulated the hepatic mRNA expression of Hmgcr in both male and female offspring and decreased the hepatic mRNA expression of Cpt1a and Acox1 in females. Both maternal and postnatal HLA diet decreased hepatic mRNA expression of Cyp27a1 in females. Postnatal diet significantly altered circulating fatty acid concentrations, with sex-specific differences in genes that control lipid metabolism in the adult offspring following exposure to high LA diet in utero.
Details
- Title
- Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner
- Authors
- Nirajan Shrestha (Author) - Griffith UniversityJosif Vidimce (Author) - Griffith UniversityOlivia J. Holland (Author) - Griffith UniversityJames S. M. Cuffe (Author) - The University of QueenslandBelinda R. Beck (Author) - Griffith UniversityAnthony V. Perkins (Author) - Griffith UniversityAndrew J. McAinch (Author) - Victoria UniversityDeanne H. Hryciw (Author) - Victoria University
- Publication details
- International Journal of Molecular Sciences, Vol.22(6), pp.1-23
- Publisher
- MDPI AG
- Date published
- 2021
- DOI
- 10.3390/ijms22062946
- ISSN
- 1422-0067; 1661-6596
- PMID
- 33799409
- Grant note
- Griffith University Postgraduate Research Scholarship (GUPRS-NS) Australian Government's Collaborative Research Networks (CRN) program; Australian Government Allen Foundation (USA) Griffith Health Top Up Scholarship Allen Foundation, Inc. Griffith University International Postgraduate Research Scholarship (GUIPRSNS)
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685193502621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
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