Maternal adaptations and inheritance in the transgenerational programming of adult disease

Linda A. Gallo; Melanie Tran; Jordanna S. Master; Karen M. Moritz; Mary E. Wlodek

doi:10.1007/s00441-012-1411-y

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Maternal adaptations and inheritance in the transgenerational programming of adult disease

Journal article

Peer reviewed

Maternal adaptations and inheritance in the transgenerational programming of adult disease

Linda A. Gallo, Melanie Tran, Jordanna S. Master, Karen M. Moritz and Mary E. Wlodek

Cell and Tissue Research, Vol.349(3), pp.863-880

2012

DOI: https://doi.org/10.1007/s00441-012-1411-y

PMID: 22526629

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Abstract

Transgenerational

Developmental programming

Fetal growth restriction

Maternal pregnancy adaptations

Second-hit

Adverse exposures in utero have long been linked with an increased susceptibility to adult cardio-renal and metabolic diseases. Clear gender differences exist, whereby growth-restricted females, although exhibiting some phenotypic modifications, are often protected from overt disease outcomes. One of the greatest physiological challenges facing the female gender, however, is that of pregnancy; yet little research has focused on the outcomes associated with this, as a potential 'second-hit' for those who were small at birth. We review the limited evidence suggesting that pregnancy may unmask cardio-renal and metabolic disease states and the consequences for long-term maternal health in females who were born small. Additionally, a growing area of research in this programming field is in the transgenerational transmission of low birth weight and disease susceptibility. Pathways for transmission might include an abnormal adaptation to pregnancy by the growth-restricted mother and/or inheritance via the parental germline. Strategies to optimise the pregnancy environment and/or prevent the consequences of inheritance of programmed deficits and dysfunction are of critical importance for future generations.

Details

Title: Maternal adaptations and inheritance in the transgenerational programming of adult disease
Authors: Linda A. Gallo (Author) - University of Melbourne
Melanie Tran (Author) - University of Melbourne
Jordanna S. Master (Author) - University of Melbourne
Karen M. Moritz (Author) - University of Queensland
Mary E. Wlodek (Corresponding Author) - University of Melbourne
Publication details: Cell and Tissue Research, Vol.349(3), pp.863-880
Publisher: Springer
DOI: 10.1007/s00441-012-1411-y
ISSN: 1432-0878
PMID: 22526629
Organisation Unit: School of Health - Biomedicine; School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99679193502621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Cell Biology

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