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Maternal Selenium Deficiency in Mice Alters Offspring Glucose Metabolism and Thyroid Status in a Sexually Dimorphic Manner806.85 kB
Published VersionCC BY V4.0, Open Access
Journal article
Maternal Selenium Deficiency in Mice Alters Offspring Glucose Metabolism and Thyroid Status in a Sexually Dimorphic Manner
Nutrients, Vol.12(1), pp.1-16
2020
PMCID: PMC7020085
PMID: 31968625
Abstract
Selenium is an essential micronutrient commonly deficient in human populations. Selenium deficiency increases the risks of pregnancy complications; however, the long-term impact of selenium deficiency on offspring disease remains unclear. This study investigates the effects of selenium deficiency during pregnancy on offspring metabolic function. Female C57BL/6 mice were allocated to control (>190 μg selenium/kg, n = 8) or low selenium (<50 μg selenium/kg, n = 8) diets prior to mating and throughout gestation. At postnatal day (PN) 170, mice underwent an intraperitoneal glucose tolerance test and were culled at PN180 for biochemical analysis. Mice exposed to selenium deficiency in utero had reduced fasting blood glucose but increased postprandial blood glucose concentrations. Male offspring from selenium-deficient litters had increased plasma insulin levels in conjunction with reduced plasma thyroxine (tetraiodothyronine or T4) concentrations. Conversely, females exposed to selenium deficiency in utero exhibited increased plasma thyroxine levels with no change in plasma insulin. This study demonstrates the importance of adequate selenium intake around pregnancy for offspring metabolic health. Given the increasing prevalence of metabolic disease, this study highlights the need for appropriate micronutrient intake during pregnancy to ensure a healthy start to life.
Details
- Title
- Maternal Selenium Deficiency in Mice Alters Offspring Glucose Metabolism and Thyroid Status in a Sexually Dimorphic Manner
- Authors
- Pierre Hofstee (Author) - Griffith UniversityDaniel R. McKeating (Author) - Griffith UniversityLucy A. Bartho (Author) - Griffith UniversityStephen T. Anderson (Author) - Griffith UniversityAnthony V. Perkins (Author) - Griffith UniversityJames S. M. Cuffe (Corresponding Author) - Griffith University
- Publication details
- Nutrients, Vol.12(1), pp.1-16
- Publisher
- MDPI AG
- Date published
- 2020
- DOI
- 10.3390/nu12010267
- ISSN
- 2072-6643
- PMID
- 31968625; PMC7020085
- Copyright note
- © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685196802621
- Output Type
- Journal article
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- Domestic collaboration
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- Nutrition & Dietetics
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