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Published VersionCC BY V4.0, Open Access
Journal article
Maternal High Linoleic Acid Alters Placental Fatty Acid Composition
Nutrients, Vol.12(8), pp.1-14
2020
PMID: 32717842
Abstract
Fetal development is modulated by maternal nutrition during pregnancy. The dietary intake of linoleic acid (LA), an essential dietary n-6 polyunsaturated fatty acid (PUFA), has increased. We previously published that increased LA consumption during pregnancy does not alter offspring or placental weight but fetal plasma fatty acid composition; the developing fetus obtains their required PUFA from the maternal circulation. However, it is unknown if increased maternal linoleic acid alters placental fatty acid storage, metabolism, transport, and general placental function. Female Wistar-Kyoto rats were fed either a low LA diet (LLA; 1.44% of energy from LA) or high LA diet (HLA; 6.21% of energy from LA) for 10 weeks before pregnancy and during gestation. Rats were sacrificed at embryonic day 20 (E20, term = 22 days) and placentae collected. The labyrinth of placentae from one male and one female fetus from each litter were analyzed. High maternal LA consumption increased placental total n-6 and LA concentrations, and decreased total n-3 PUFA, alpha-linolenic acid (ALA), and docosahexaenoic acid (DHA). Fatty acid desaturase 1 (Fads1), angiopoietin-like 4 (Angptl4), and diacylglycerol lipase beta (Daglb) mRNA were downregulated in placentae from offspring from HLA dams. Maternal high LA downregulated the fatty acid transport protein 4 (Fatp4) and glucose transporter 1 (Slc2a1) mRNA in placentae. IL-7 and IL-10 protein were decreased in placentae from offspring from HLA dams. In conclusion, a high maternal LA diet alters the placental fatty acid composition, inflammatory proteins, and expressions of nutrient transporters, which may program deleterious outcomes in offspring.
Details
- Title
- Maternal High Linoleic Acid Alters Placental Fatty Acid Composition
- Authors
- Nirajan Shrestha (Author) - Griffith UniversityOlivia J. Holland (Author) - Griffith UniversityNykola L. Kent (Author) - The University of QueenslandAnthony V. Perkins (Author) - Griffith UniversityAndrew J. McAinch (Author) - Victoria UniversityJames S. M. Cuffe (Author) - The University of QueenslandDeanne H. Hryciw (Corresponding Author) - Victoria University
- Publication details
- Nutrients, Vol.12(8), pp.1-14
- Publisher
- MDPI AG
- Date published
- 2020
- DOI
- 10.3390/nu12082183
- ISSN
- 2072-6643
- PMID
- 32717842
- Copyright note
- © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Grant note
- Australian Government's Collaborative Research Networks (C.R.N.) program; Australian Government Griffith University International Postgraduate Research Scholarship (GUIPRS) Griffith University Postgraduate Research Scholarship (GUPRS) Griffith Health Top Up Scholarship Allen Foundation, Inc.
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685196902621
- Output Type
- Journal article
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