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Published VersionCC BY V4.0, Open Access
Journal article
Maternal Diet High in Linoleic Acid Alters Offspring Lipids and Hepatic Regulators of Lipid Metabolism in an Adolescent Rat Model
International Journal of Molecular Sciences, Vol.25(2), pp.1-11
2024
PMID: 38256199
Abstract
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. A maternal high LA (HLA) diet alters cardiovascular development in adolescent rats and hepatic function in adult rats in a sex-specific manner. We investigated the effects of an HLA diet on adolescent offspring hepatic lipids and hepatic lipid metabolism gene expression, and the ability of the postnatal diet to alter these effects. Female Wistar Kyoto rats were fed low LA (LLA; 1.44% energy from LA) or high LA (HLA; 6.21% energy from LA) diets during pregnancy and gestation/lactation. Offspring, weaned at postnatal day (PN) 25, were fed LLA or HLA and euthanised at PN40 (n = 6–8). Maternal HLA increased circulating uric acid, decreased hepatic cholesterol and increased hepatic Pparg in males, whereas only hepatic Srebf1 and Hmgcr increased in females. Postnatal (post-weaning) HLA decreased liver weight (% body weight) and increased hepatic Hmgcr in males, and decreased hepatic triglycerides in females. Maternal and postnatal HLA had an interaction effect on Lpl, Cpt1a and Pparg in females. These findings suggest that an HLA diet both during and after pregnancy should be avoided to improve offspring disease risk.
Details
- Title
- Maternal Diet High in Linoleic Acid Alters Offspring Lipids and Hepatic Regulators of Lipid Metabolism in an Adolescent Rat Model
- Authors
- Nirajan Shrestha (Author) - Griffith UniversitySimone L Sleep (Author) - Griffith UniversityOlivia J Holland (Author) - Griffith UniversityJosif Vidimce (Author) - Griffith UniversityAndrew C Bulmer (Author) - Griffith UniversityJames S M Cuffe (Author) - The University of QueenslandAnthony V Perkins (Author) - University of the Sunshine Coast, Queensland, School of HealthAndrew J McAinch (Author) - Victoria UniversityDeanne H Hryciw (Corresponding Author) - Victoria University
- Publication details
- International Journal of Molecular Sciences, Vol.25(2), pp.1-11
- Publisher
- MDPI AG
- Date published
- 2024
- DOI
- 10.3390/ijms25021129
- ISSN
- 1422-0067
- PMID
- 38256199
- Copyright note
- © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Data Availability
- Data are contained within the article.
- Grant note
- This research was supported by the Allen Foundation, Inc. (2015.325: DHH, AJM), and through the Australian Government’s Collaborative Research Networks (CRN) program (AJM). Scholarship funding is provided by Griffith University International Postgraduate Research Scholarship (GUIPRS-NS), Griffith University Postgraduate Research Scholarship (GUPRS-NS) and Griffith Health Top Up Scholarship (NS). This research was in part funded by the Allen Foundation (USA).
- Organisation Unit
- School of Health - Biomedicine; School of Health
- Language
- English
- Record Identifier
- 99994185402621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
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