Journal article
Mapping the trajectory of acute mild-stroke cognitive recovery using serial computerised cognitive assessment
Brain Impairment, Vol.24(3), pp.629-648
2023
PMID: 38167363
Abstract
Introduction: Cognitive impairment is common post stroke. There is a need to understand patterns of early cognitive recovery post stroke to guide both clinical and research practice. The aim of the study was to map the trajectory of cognitive recovery during the first week to 90 days post stroke using serial computerised assessment. Method: An observational cohort study recruited consecutive stroke patients admitted to a stroke unit within 48 hours of onset. Cognitive function was assessed using the computerised Cambridge Neuropsychological Test Automated Battery (CANTAB) daily for seven days, then 14, 30 and 90 days post stroke. The CANTAB measured visual episodic memory and learning, information processing speed, visuo spatial working memory, complex sustained attention and mental flexibility. Repeated measures MANOVA/ANOVA with Least Squares Difference post hoc analyses were performed to ascertain significant change over time. Result: Forty eight participants, mean age 73, primarily mild, ischaemic stroke, completed all assessment timepoints. There was a trajectory of early, global cognitive improvement, indicative of a post stroke delirium , that largely stabilised between 6 and 14 days pos stroke. Change over time was examined within each cognitive test, with one measure stabilising by day 6 (Reaction Time) and others detecting improving performances up to 14 days post stroke. Conclusions: Serial, computerised cognitive assessment can effectively map post stroke cognitive recovery and revealed an early phase of global improvement over 14 days that is evidence for an acute post stroke delirium. Resolution of post stroke delirium in the second week following mild stroke indicates more extensive neuropsychological testing may be undertaken earlier than previously thought.
Details
- Title
- Mapping the trajectory of acute mild-stroke cognitive recovery using serial computerised cognitive assessment
- Authors
- Alana Campbell (Corresponding Author) - Sunshine Coast University Hospital (Australia)Louise Gustafsson (Author) - Griffith UniversityRohan S Grimley (Author) - Griffith UniversityHannah Gullo (Author) - The University of QueenslandIngrid Rosbergen (Author) - Sunshine Coast Hospital and Health ServiceMathew Summers (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
- Publication details
- Brain Impairment, Vol.24(3), pp.629-648
- Publisher
- Cambridge University Press
- Date published
- 2023
- DOI
- 10.1017/BrImp.2022.24
- ISSN
- 1839-5252
- PMID
- 38167363
- Copyright note
- © The Author(s), 2022. Published by Cambridge University Press on behalf of Australasian Society for the Study of Brain Impairment.
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99681397102621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Rehabilitation
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