Journal article
Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation
Blood, Vol.112(5), pp.2120-2128
2008
PMID: 18552214
Abstract
Mannose-binding lectin (MBL) is a mediator of innate immunity that influences the risk of infection in a range of clinical settings. We previously reported associations between MBL2 genotype and infection in a retrospective study of myeloablative allogeneic hematopoietic stem cell transplantation (allo-HCT). However, other studies have been inconclusive, and the role of MBL in reduced-intensity conditioning (RIC) transplantation is unknown. Here we report a prospective study examining MBL2 genotype, MBL levels, and risk of major infection following HLA-matched sibling myeloablative (n = 83) and RIC (n = 59) HCT. Baseline MBL levels were higher in recipients than donors (P < .001), and recipient MBL levels increased during the peritransplantation period (P = .001), most notably in MBL2 wild-type individuals receiving myeloablative total body irradiation (mTBI). MBL2 coding mutations were associated with major infection in recipients receiving mTBI. The cumulative incidence of major infection in recipient harboring an MBL2 mutation receiving mTBI was 70.6%, compared with 31.1% of those without mutations not receiving mTBI (P = .01). MBL status was not associated with infection in RIC transplants. These results confirm the association of MBL status with risk of infection in myeloablative, TBI-conditioned transplantation. Studies examining the role of MBL replacement therapy to prevent infection in this setting should be considered.
Details
- Title
- Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation
- Authors
- Charles G Mullighan (Corresponding Author) - Australian Red Cross Blood ServiceSusan L Heatley - Australian Red Cross Blood ServiceSilke Danner - Australian Red Cross Blood ServiceMelinda M Dean - Australian Red Cross Blood ServiceKathleen Doherty - Australian Red Cross Blood ServiceUwe Hahn - South Australia PathologyKenneth F Bradstock - Westmead HospitalRobyn Minchinton - Australian Red Cross Blood ServiceAnthony P Schwarer - The Alfred HospitalJeff Szer - Royal Melbourne HospitalPeter G Bardy (Corresponding Author) - Australian Red Cross Blood Service
- Publication details
- Blood, Vol.112(5), pp.2120-2128
- Publisher
- American Society of Hematology
- Date published
- 2008
- DOI
- 10.1182/blood-2007-07-100222
- ISSN
- 1528-0020
- PMID
- 18552214
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991037506502621
- Output Type
- Journal article
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- Domestic collaboration
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- Hematology
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Source: InCites