Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

I B Hickie; S L Naismith; R Robillard; E M Scott; Daniel F Hermens

doi:10.1186/1741-7015-11-79

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Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

Journal article

Open access

Peer reviewed

Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

I B Hickie, S L Naismith, R Robillard, E M Scott and Daniel F Hermens

BMC Medicine, Vol.11(1), 79

2013

DOI: https://doi.org/10.1186/1741-7015-11-79

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Abstract

major depression

sleep-wake cycle

circadian rhythms

Background: Clinical psychiatry has always been limited by the lack of objective tests to substantiate diagnoses and a lack of specific treatments that target underlying pathophysiology. One area in which these twin failures has been most frustrating is major depression. Due to very considerable progress in the basic and clinical neurosciences of sleep-wake cycles and underlying circadian systems this situation is now rapidly changing.Discussion: The development of specific behavioral or pharmacological strategies that target these basic regulatory systems is driving renewed clinical interest. Here, we explore the extent to which objective tests of sleep-wake cycles and circadian function - namely, those that measure timing or synchrony of circadian-dependent physiology as well as daytime activity and nighttime sleep patterns - can be used to identify a sub-class of patients with major depression who have disturbed circadian profiles.Summary: Once this unique pathophysiology is characterized, a highly personalized treatment plan can be proposed and monitored. New treatments will now be designed and old treatments re-evaluated on the basis of their effects on objective measures of sleep-wake cycles, circadian rhythms and related metabolic systems. © 2013 Hickie et al.; licensee BioMed Central Ltd.

Details

Title: Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression
Authors: I B Hickie (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
R Robillard (Author) - University of Sydney
E M Scott (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
Publication details: BMC Medicine, Vol.11(1), 79
Publisher: BioMed Central Ltd.
Date published: 2013
DOI: 10.1186/1741-7015-11-79
ISSN: 1741-7015
Copyright note: Copyright © Hickie et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451101002621
Output Type: Journal article

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