Manipulating IL-10 signalling blockade for better immunotherapy

Guoying Ni; Tianfang Wang; Shelley F Walton; Bin Zhu; Shu Chen; Xiaolian Wu; Yuejian Wang; Ming Q Wei; Xiao Song Liu

doi:10.1016/j.cellimm.2014.12.012

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Manipulating IL-10 signalling blockade for better immunotherapy

Journal article

Peer reviewed

Manipulating IL-10 signalling blockade for better immunotherapy

Guoying Ni, Tianfang Wang, Shelley F Walton, Bin Zhu, Shu Chen, Xiaolian Wu, Yuejian Wang, Ming Q Wei and Xiao Song Liu

Cellular Immunology, Vol.293(2), pp.126-129

2015

DOI: https://doi.org/10.1016/j.cellimm.2014.12.012

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Abstract

interleukin 10

immunotherapy

vaccine

Interleukin 10 is a cytokine with the ability to reduce or terminate inflammation. Chronic viral infection, such as infection of chronic hepatitis B, hepatitis C and HIV, has increased levels of interleukin 10 in peripheral blood. Serum IL-10 levels are also high in certain cancers. Blocking IL-10 signalling at the time of immunisation clears chronic viral infection and prevents tumour growth in animal models. We review recent advances in this area, with the emphasis on potential use of this novel strategy to treat chronic viral infection and cancer in human.

Details

Title: Manipulating IL-10 signalling blockade for better immunotherapy
Authors: Guoying Ni (Author) - Griffith University
Tianfang Wang (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Shelley F Walton (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Bin Zhu (Author) - Foshan First People's Hospital, China
Shu Chen (Author) - Foshan First People's Hospital, China
Xiaolian Wu (Author) - Foshan First People's Hospital, China
Yuejian Wang (Author) - Foshan First People's Hospital, China
Ming Q Wei (Author) - Griffith University
Xiao Song Liu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Cellular Immunology, Vol.293(2), pp.126-129
Publisher: Academic Press
Date published: 2015
DOI: 10.1016/j.cellimm.2014.12.012
ISSN: 0008-8749
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449394102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Cell Biology; Immunology

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