Managing passively acquired autoimmune neonatal neutropenia

Yoke Lin Fung; L A Pitcher; K Taylor; R M Minchinton

doi:10.1111/j.0958-7578.2005.00565.x

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Managing passively acquired autoimmune neonatal neutropenia

Journal article

Peer reviewed

Managing passively acquired autoimmune neonatal neutropenia

Yoke Lin Fung, L A Pitcher, K Taylor and R M Minchinton

Transfusion Medicine, Vol.15(2), pp.151-155

2005

DOI: https://doi.org/10.1111/j.0958-7578.2005.00565.x

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Abstract

Clinical Sciences

autoimmune neutropenia

G-CSF

neonatal neutropenia

passively acquired.

Pregnant women with autoimmune neutropenia (AIN) and circulating neutrophil-specific autoantibodies can deliver neutropenic neonates at risk of sepsis. We report the case of a woman who had two such pregnancies. The woman had been on prophylactic granulocyte colony-stimulating factor (G-CSF) treatment, but this was ceased prior to conception in both pregnancies. In the first pregnancy, there was no monitoring or interventions, and the neonate was neutropenic and required intensive care treatment. In the second pregnancy, the maternal neutrophil autoantibody level was monitored, and G-CSF treatment was introduced in the third trimester. The second infant had no neutropenia at delivery and an excellent Apgar score. We discuss the management strategy in the second pregnancy that included monitoring of serial titres of the maternal autoantibody and the introduction of G-CSF in the third trimester, which may have contributed to a more favourable clinical outcome. This may assist other clinicians faced with similar dilemmas in the future.

Details

Title: Managing passively acquired autoimmune neonatal neutropenia
Authors: Yoke Lin Fung (Author) - Australian Red Cross Blood Service
L A Pitcher (Author) - Starship Children's Hospital, New Zealand
K Taylor (Author) - Mater Hospital
R M Minchinton (Author) - Australian Red Cross Blood Service
Publication details: Transfusion Medicine, Vol.15(2), pp.151-155
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2005
DOI: 10.1111/j.0958-7578.2005.00565.x
ISSN: 0958-7578
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449471002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Hematology

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