Management of basal cell carcinoma with pulmonary metastasis

Samuel Achilles Fordham; Emily Ximin Shao; Leith Banney; Mary Azer; Andrew Dettrick

doi:10.1136/bcr-2022-251700

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Management of basal cell carcinoma with pulmonary metastasis

Journal article

Peer reviewed

Management of basal cell carcinoma with pulmonary metastasis

Samuel Achilles Fordham, Emily Ximin Shao, Leith Banney, Mary Azer and Andrew Dettrick

BMJ Case Reports, Vol.16(1), pp.1-6

2023

DOI: https://doi.org/10.1136/bcr-2022-251700

PMID: 36599494

Appears in Cancer Research Cluster Research Collection

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Abstract

A man in his 50s presented with an ulcerative lesion within the left axillary fold that had progressively worsened over 18 months. Biopsy revealed an ulcerative basal cell carcinoma (BCC), which was surgically managed. CT chest scans done 7 months later assessed post-treatment of radiotherapy. This revealed pulmonary lesions, which were biopsy-proven metastatic BCC. Sonidegib, a hedgehog signalling inhibitor, was used for first-line treatment. Due to progressive disease, sonidegib was ceased. Cemiplimab, a checkpoint inhibitor, was used as second-line treatment based on a phase II trial demonstrating efficacy in the setting of metastatic BCC. CT reports were initially consistent with response but after 6 months of cemiplimab treatment, repeat CT chest scans revealed a decrease in size of the previously cited pulmonary lesions.This is a rare case of BCC metastases which has limited treatment options. This case provides insight of the patient experience on such treatment.

Details

Title: Management of basal cell carcinoma with pulmonary metastasis
Authors: Samuel Achilles Fordham (Corresponding Author) - Sunshine Coast University Hospital
Emily Ximin Shao (Author) - Royal Brisbane and Women's Hospital
Leith Banney (Author) - Sunshine Coast University Hospital
Mary Azer (Author) - Sunshine Coast University Hospital
Andrew Dettrick (Author) - University of the Sunshine Coast
Publication details: BMJ Case Reports, Vol.16(1), pp.1-6
Publisher: BMJ Group
Date published: 2023
DOI: 10.1136/bcr-2022-251700
ISSN: 1757-790X
PMID: 36599494
Organisation Unit: School of Health; Cancer Research Cluster
Language: English
Record Identifier: 99716195102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Oncology

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