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Mammographic density - a potential monitoring biomarker for adjuvant and preventative breast cancer endocrine therapies971.27 kB
Published VersionCC BY V3.0, Open Access
Journal article
Mammographic density: a potential monitoring biomarker for adjuvant and preventative breast cancer endocrine therapies
Oncotarget, Vol.8(3), pp.5578-5591
2017
PMCID: PMC5354931
PMID: 27894075
Abstract
Increased mammographic density (MD) has been shown beyond doubt to be a marker for increased breast cancer risk, though the underpinning pathobiology is yet to be fully elucidated. Estrogenic activity exerts a strong influence over MD, which consequently has been observed to change predictably in response to tamoxifen anti-estrogen therapy, although results for other selective estrogen receptor modulators and aromatase inhibitors are less consistent. In both primary and secondary prevention settings, tamoxifen-associated MD changes correlate with successful modulation of risk or outcome, particularly among pre-menopausal women; an observation that supports the potential use of MD change as a surrogate marker where short-term MD changes reflect longer-term anti-estrogen efficacy. Here we summarize endocrine therapy-induced MD changes and attendant outcomes and discuss both the need for outcome surrogates in such therapy, as well as make a case for MD as such a monitoring marker. We then discuss the process and steps required to validate and introduce MD into practice as a predictor or surrogate for endocrine therapy efficacy in preventive and adjuvant breast cancer treatment settings.
Details
- Title
- Mammographic density: a potential monitoring biomarker for adjuvant and preventative breast cancer endocrine therapies
- Authors
- Michael S Shawky (Author) - Alexandria UniversityHilary Martin (Author) - Fiona Stanley HospitalHonor J Hugo (Author) - Queensland University of TechnologyThomas Lloyd (Author) - Princess Alexandra HospitalKara L Britt (Author) - The University of MelbourneAndrew Redfern (Author) - The University of Western AustraliaErik W Thompson (Author) - Queensland University of Technology
- Publication details
- Oncotarget, Vol.8(3), pp.5578-5591
- Publisher
- Impact Journals LLC
- Date published
- 2017
- DOI
- 10.18632/oncotarget.13484
- ISSN
- 1949-2553
- PMID
- 27894075; PMC5354931
- Copyright note
- Oncotarget applies the Creative Commons Attribution 3.0 License (CC BY 3.0) to all works we publish (read the human-readable summary or the full license legal code). Under the CC BY, authors retain ownership of the copyright for their article, but authors allow anyone to download, reuse, reprint, modify, distribute, and/or copy articles in Oncotarget, so long as the original authors and source are cited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99516508502621
- Output Type
- Journal article
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