Journal article
Malaria antibody persistence correlates with duration of exposure
Vox Sanguinis, Vol.104(4), pp.292-298
2013
PMID: 23134513
Abstract
In Australia, the risk of transfusion-transmitted malaria is managed through the identification of 'at-risk' donors, antibody screening enzyme-linked immunoassay (EIA) and, if reactive, exclusion from fresh blood component manufacture. Donor management depends on the duration of exposure in malarious regions (>6 months: 'Resident', <6 months: 'Visitor') or a history of malaria diagnosis. We analysed antibody testing and demographic data to investigate antibody persistence dynamics. To assess the yield from retesting 3 years after an initial EIA reactive result, we estimated the proportion of donors who would become non-reactive over this period.
Test results and demographic data from donors who were malaria EIA reactive were analysed. Time since possible exposure was estimated and antibody survival modelled.
Among seroreverters, the time since last possible exposure was significantly shorter in 'Visitors' than in 'Residents'. The antibody survival modelling predicted 20% of previously EIA reactive 'Visitors', but only 2% of 'Residents' would become non-reactive within 3 years of their first reactive EIA.
Antibody persistence in donors correlates with exposure category, with semi-immune 'Residents' maintaining detectable antibodies significantly longer than non-immune 'Visitors'.
Details
- Title
- Malaria antibody persistence correlates with duration of exposure
- Authors
- Helen Faddy (Author) - Australian Red Cross Blood ServiceClive Seed (Author) - Australian Red Cross Blood ServiceM J Faddy (Author) - Queensland University of TechnologyRobert Flower (Author) - Australian Red Cross Blood ServiceRobert Harley (Author) - Australian Red Cross Blood Service
- Publication details
- Vox Sanguinis, Vol.104(4), pp.292-298
- Publisher
- Wiley-Blackwell Publishing Ltd.
- DOI
- 10.1111/vox.12000
- ISSN
- 1423-0410
- PMID
- 23134513
- Organisation Unit
- School of Health - Biomedicine; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99477805702621
- Output Type
- Journal article
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- Domestic collaboration
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- Hematology
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