Files and links (1)
Published VersionCC BY V4.0, Open Access
Journal article
Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults
Translational Vision Science & Technology, Vol.10(3), pp.1-11
2021
PMID: 34003942
Abstract
Purpose: To describe the thickness profiles of the full retinal and outer retinal layers (ORL) at the macula in healthy young adults, and associations with best-corrected visual acuity (BCVA).
Methods: In total, 1604 participants (19-30 years) underwent an eye examination that included measurements of their BCVA, axial length, and autorefraction. The retinal thickness at the foveal pit and at the nine Early Treatment of Diabetic Retinopathy Study macular regions (0.5-mm radius around the fovea, and superior, inferior, temporal, and nasal quadrants of the inner and outer rings of the macula) were obtained using spectral domain optical coherence tomography imaging. A custom program was used to correct for transverse magnification effects because of different axial lengths.
Results: The median full retinal and ORL thicknesses at the central macula were 285 mu m and 92 mu m. The full retina was thinnest centrally and thickest at the inner macula ring, whereas the ORL was thickest centrally and gradually decreased in thickness with increasing eccentricity. There was no association between axial length and the full retinal or ORL thickness. Increased thicknesses of the full retina at the central macula was associated with better BCVA; however, the effect size was small and not clinically significant. Conclusions: This article mapped the full retinal and ORL thickness profile in a population-based sample of young healthy adults.
Translational Relevance: Thickness values presented in this article could be used as a normative reference for future studies on young adults and in clinical practice.
Details
- Title
- Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults
- Authors
- Samantha Sze-Yee Lee (Corresponding Author) - The University of Western AustraliaGareth Lingham (Author) - The University of Western AustraliaDavid Alonso-Caneiro (Author) - Queensland University of TechnologyJason Charng (Author) - The University of Western AustraliaFred Kuanfu Chen (Author) - The University of Western AustraliaSeyhan Yazar (Author) - The University of Western AustraliaDavid Anthony Mackey (Author) - The University of Western Australia
- Publication details
- Translational Vision Science & Technology, Vol.10(3), pp.1-11
- Publisher
- Association for Research in Vision and Ophthalmology
- Date published
- 2021
- DOI
- 10.1167/tvst.10.3.8
- ISSN
- 2164-2591
- PMID
- 34003942
- Copyright note
- This work is licensed under a Creative Commons Attribution 4.0 International License.
- Grant note
- Ophthalmic Research Institute of Australia (ORIA) Women and Infants Research Foundation University of Notre Dame Australia GNT1021105 / Australian National Health and Medical Research Council (NHMRC); National Health and Medical Research Council (NHMRC) of Australia Murdoch University Alcon Research Institute; Novartis NHMRC Early Career Fellowship; National Health and Medical Research Council (NHMRC) of Australia MRF1142962 / Medical Research Future Fund Career Development Fellowship; Medical Research Future Fund (MRFF) NHMRC Practitioner Fellowship; National Health and Medical Research Council (NHMRC) of Australia Edith Cowan University Australian Foundation for the Prevention of Blindness Curtin University University of Western Australia Lions Eye Institute Telethon Kids Institute Raine Medical Research Foundation
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99972393702621
- Output Type
- Journal article
Metrics
32 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Ophthalmology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites