Journal article
Macrolide antibiotics, drug interactions and microsomal enzymes: Implications for veterinary medicine
Research in Veterinary Science, Vol.66(3), pp.197-203
1999
Abstract
The macrolide group of antibiotics includes natural members, pro-drugs and semi-synthetic derivatives, thus named because they are composed of a large aglycone ring (from 14 to 16 carbon atoms), to which are attached several sugars. Some of them are aminosugars, containing a diethylamino, tertiary amine function. A number of antibiotics, including erythromycin, oleandomycin, triacetyl-oleandomycin (troleandomycin), carbomycin, spiramycin, tylosin, rosamicin, azithromycin, clarithromycin, dirithromycin and others, are members of this group. On a comparative basis, erythromycin and oleandomycin are similar, with the same basic 14-carbon lactone ring and side chain sugars. The remaining compounds contain a basic 15- or 16-carbon lactone ring and one or two side-chain sugars. Most of the macrolides are produced by Streptomyces spp bacteria. An exception is rosamicin, which is produced by Micromonospora. Clarithromycin and azithromycin are new semi-synthetic derivatives of erythromycin.
Details
- Title
- Macrolide antibiotics, drug interactions and microsomal enzymes: Implications for veterinary medicine
- Authors
- A Anadón (Author) - Universidad Complutense de Madrid, SpainLloyd Reeve-Johnson (Author) - Elanco Animal Science Research, United Kingdom
- Publication details
- Research in Veterinary Science, Vol.66(3), pp.197-203
- Publisher
- Elsevier Ltd.
- Date published
- 1999
- DOI
- 10.1053/rvsc.1998.0244
- ISSN
- 0034-5288
- Organisation Unit
- Faculty of Science, Health, Education and Engineering; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99451305802621
- Output Type
- Journal article
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