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Machine learning vs addiction therapists - A pilot study predicting alcohol dependence treatment outcome from patient data in behavior therapy with adjunctive medication549.50 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Machine learning vs addiction therapists: A pilot study predicting alcohol dependence treatment outcome from patient data in behavior therapy with adjunctive medication
Journal of Substance Abuse Treatment, Vol.99, pp.156-162
2019
PMID: 30797388
Abstract
Background and objectives:
Clinical staff providing addiction treatment predict patient outcome poorly. Prognoses based on linear statistics are rarely replicated. Addiction is a complex non-linear behavior. Incorporating non-linear models, Machine Learning (ML) has successfully predicted treatment outcome when applied in other areas of medicine. Using identical assessment data across the two groups, this study compares the accuracy of ML models versus clinical staff to predict alcohol dependence treatment outcome in behavior therapy using patient data only.
Methods:
Machine learning models (n = 28) were constructed (‘trained’) using demographic and psychometric assessment data from 780 previously treated patients who had undertaken a 12 week, abstinence-based Cognitive Behavioral Therapy program for alcohol dependence. Independent predictions applying assessment data for an additional 50 consecutive patients were obtained from 10 experienced addiction therapists and the 28 trained ML models. The predictive accuracy of the ML models and the addiction therapists was then compared with further investigation of the 10 best models selected by cross-validated accuracy on the training-set. Variables selected as important for prediction by staff and the most accurate ML model were examined.
Results:
The most accurate ML model (Fuzzy Unordered Rule Induction Algorithm, 74%) was significantly more accurate than the four least accurate clinical staff (51%–40%). However, the robustness of this finding may be limited by the moderate area under the receiver operator curve (AUC = 0.49). There was no significant difference in mean aggregate predictive accuracy between 10 clinical staff (56.1%) and the 28 best models (58.57%). Addiction therapists favoured demographic and consumption variables compared with the ML model using more questionnaire subscales.
Conclusions:
The majority of staff and ML models were not more accurate than suggested by chance. However, the best performing prediction models may provide useful adjunctive information to standard clinically available prognostic data to more effectively target treatment approaches in clinical settings.
Details
- Title
- Machine learning vs addiction therapists: A pilot study predicting alcohol dependence treatment outcome from patient data in behavior therapy with adjunctive medication
- Authors
- Martyn Symons (Author) - Princess Alexandra HospitalGerald F.X Feeney (Author) - Princess Alexandra HospitalMarcus R Gallagher (Author) - The University of QueenslandRoss Young (Author) - Queensland University of TechnologyJason P Connor (Author) - The University of Queensland
- Publication details
- Journal of Substance Abuse Treatment, Vol.99, pp.156-162
- Publisher
- Elsevier Inc.
- Date published
- 2019
- DOI
- 10.1016/j.jsat.2019.01.020
- ISSN
- 1873-6483; 0740-5472
- PMID
- 30797388
- Copyright note
- Copyright © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550993402621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Psychology, Clinical
- Substance Abuse
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